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HOXD13 — SHH
Text-mined interactions from Literome
Kimura et al., Dev Growth Differ 2000
:
This result indicates that
Hoxd-13 activation by
SHH depends on non-ridge ectoderm and FGF-2 or FGF-4, and that there may be a difference in the effect on AP axis formation of the limb bud between FGF-2, -4 and -8
Lin et al., Development 2009
:
By restoring Wnt-Fgf8 signaling in Shh ( -/- ) cloacal endoderm genetically, we revealed that
Shh relays its signal partly through the dUE, but
regulates Hoxa13 and
Hoxd13 expression independently of dUE signaling
Galli et al., PLoS Genet 2010
:
In wild-type limb buds, Hand2 is part of the protein complexes containing
Hoxd13 , another essential
regulator of
Shh activation in limb buds
Grieshammer et al., Development 1996
:
In contrast,
SHH is not
required for the induction of Hoxd11 or
Hoxd13 expression, since expression of both these genes was detected in the mutant limb buds
Roberts et al., Development 1998
:
In addition to the regional restriction on Bmp4 induction,
Shh can only
induce Hoxd-13 in the mesoderm of the hindgut