Gene interactions and pathways from curated databases and text-mining

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HOXD13 — SHH

Text-mined interactions from Literome

Kimura et al., Dev Growth Differ 2000 : This result indicates that Hoxd-13 activation by SHH depends on non-ridge ectoderm and FGF-2 or FGF-4, and that there may be a difference in the effect on AP axis formation of the limb bud between FGF-2, -4 and -8
Lin et al., Development 2009 : By restoring Wnt-Fgf8 signaling in Shh ( -/- ) cloacal endoderm genetically, we revealed that Shh relays its signal partly through the dUE, but regulates Hoxa13 and Hoxd13 expression independently of dUE signaling
Galli et al., PLoS Genet 2010 : In wild-type limb buds, Hand2 is part of the protein complexes containing Hoxd13 , another essential regulator of Shh activation in limb buds
Grieshammer et al., Development 1996 : In contrast, SHH is not required for the induction of Hoxd11 or Hoxd13 expression, since expression of both these genes was detected in the mutant limb buds
Roberts et al., Development 1998 : In addition to the regional restriction on Bmp4 induction, Shh can only induce Hoxd-13 in the mesoderm of the hindgut