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NOS2 — POLDIP2

Text-mined interactions from Literome

Giovannini et al., Neurobiol Dis 2002 (Alzheimer Disease...) : Rofecoxib ( 3 mg/kg/day, 7 days ) reduced microglia and astrocyte activation, iNOS induction , and p38MAPK activation to control levels
Lee et al., Life Sci 2003 : In addition, phosphorylations of MAPKs ( ERK 1/2, p38, JNK 1/2 ) were increased by LT. LT-induced iNOS mRNA level was inhibited by PD98059 ( MEK 1/2 inhibitor ), SB203580 ( p38 inhibitor ), and cycloheximide ( a protein synthesis blocker ), indicating that the phosphorylation of ERK 1/2 and p38 , and on-going protein synthesis are necessary for LT-induced iNOS expression
Prosperi et al., Int J Immunopathol Pharmacol 2004 (Body Weight...) : Flurbiprofen, HCT-1026 and NCX-2216 ( 15 mg/kg ) significantly attenuated the Abeta ( 1-42 ) -induced glia reaction, iNOS induction and p38MAPK activation 7 days after treatment and astrocytes reaction 21 days after treatment
Chen et al., Pharmacol Res 2005 (Glioma...) : A tyrosine kinase inhibitor ( genistein ), a protein kinase C ( PKC ) inhibitor ( Ro 31-8220 ), and a p38 mitogen activated protein kinase ( MAPK ) inhibitor ( SB 203580 ) all respectively suppressed chloroquine induced iNOS expression and NO release from C6 glioma cells
Ea et al., Arthritis Res Ther 2005 (MAP Kinase Signaling System) : Using pharmacological and cytokine inhibitors, we observed that OCP crystals induced NO production and inducible NOS mRNA activation were regulated at both the transcriptional and the translational levels ; were independent from IL-1beta gene activation ; and involved p38 and c-Jun amino-terminal kinase (JNK) mitogen activated protein kinase ( MAPK ) pathways, as further confirmed by OCP crystal induced p38 and JNK MAPK phosphorylation ... Taken together, our data suggest that the transcriptional inducible NOS response to OCP crystals involved both the p38 and the JNK MAPK pathways, probably under the control of activator protein-1
Warskulat et al., Biol Chem 1998 : The osmotic regulation of taurine transport and iNOS expression appeared independent of the MEK-Erk pathway and the p38MAPK