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IFNA2 — IFNG
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shen et al., BMC cell biology 2002
:
Rat interferon-beta and
interferon-gamma significantly inhibited rat hepatic stellate cell proliferation while rat
interferon-alpha did not
affect the cell proliferation under the same culture condition
Radaeva et al., Biochem J 2004
(Carcinoma, Hepatocellular...) :
Interferon-gamma inhibits
interferon-alpha signalling in hepatic cells : evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C
Benson et al., Graefes Arch Clin Exp Ophthalmol 1992
:
However, this expression was not maximal, and all the RPE lines tested showed a marked capacity for up-regulation of expression by culture in the
presence of
interferon-alpha ,
interferon-gamma , or tumour necrosis factor alpha, cytokines involved in immunological responses
Tamir et al., Clin Exp Immunol 2005
:
Under these circumstances,
IFN-alpha2a did not modify the DC phenotype, and the production of IL-10/IL-12 and
IFN-gamma/IL-5 by DCs and by DC-stimulated naive T cells, respectively, was
inhibited compared to the effects on DCs treated with maturation factors alone
Wysocka et al., Clin Lymphoma Myeloma 2007
(Lymphoma, T-Cell, Cutaneous...) :
Patients ' peripheral blood mononuclear cells ( PBMCs ) stimulated with the TLR7 agonist 3M-001 produced high levels of
interferon ( IFN ) -alpha , and the TLR8 agonist 3M-002 potently
induced predominantly interleukin (IL)-12 and
IFN-gamma
Chakraborty et al., J Interferon Cytokine Res 2008
(Head and Neck Neoplasms...) :
On the other hand, the stimulation of PBMC with
IFN-alpha2b maintains physiological homeostasis of CXCR3 ligands, CXCL10 and CXCL9, and
increases the secretion of
IFN-gamma
Bergmann et al., Nat Immun Cell Growth Regul 1990
(Melanoma) :
Therefore, we investigated the
effect of
interferon-alpha ( IFN-alpha ) , IFN-gamma and tumor necrosis factor ( TNF-alpha ) on the induction of LAK activity by IL-2, and the induction of
IFN-gamma and TNF-alpha by IL-2
Niederwieser et al., J Immunol 1988
:
IFN-gamma induces , as expected, a strong increase in class I MHC Ag expression as well as de novo expression of class II MHC Ag, whereas
IFN-alpha 2 only slightly increases class I MHC Ag and does not induce keratinocytes to express class II MHC Ag
Nachbaur et al., Immunobiology 1988
:
r-IFN-gamma ,
r-IFN-alpha 2c and r-IL2 strongly enhanced and r-TNF-alpha and r-TNF-beta occasionally
increased shedding of beta-2 microglobulin
Hertzog et al., Biochem Int 1989
:
Contrary to previous reports, C. parvum
induced predominantly
interferon gamma , which is normally acid labile, whereas poly I : poly C induced an acid labile
interferon alpha activity with characteristics similar to those of acid labile interferon alpha reported in serum in certain human diseases
Ishii et al., J Pharmacobiodyn 1989
:
The synergistic effect of human recombinant
interferon-alpha 2a in combination with interferon-gamma and the
induction of interferon-alpha 2a receptor by
interferon-gamma
Roberts et al., Proc Soc Exp Biol Med 1986
(Neoplasms) :
Exposure of the cells to moderate hyperthermia did not alter leukocyte production of
interferon-alpha in
response to influenza virus or
interferon-gamma in response to the mitogen phytohemagglutinin
Auböck et al., Arch Dermatol Res 1985
:
HLA-DR expression was
induced by the supernatants and human recombinant
interferon-gamma ( rIFN-gamma ), whereas recombinant
interferon-alpha 2 , interleukin-2 and non-recombinant human interferon-beta had no such effect
Zhou et al., J Interferon Cytokine Res 1995
(Leukemia L1210) :
Exogenous
interferon-gamma induces endogenous synthesis of
interferon-alpha and -beta by murine macrophages for induction of nitric oxide synthase
Turpaev et al., Eur J Biochem 1996
:
The Trp-tRNA synthetase gene is
induced by
interferon-gamma in both lines and, in MT-4 lymphocytes, also by
interferon-alpha