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COA1 — GCG
Text-mined interactions from Literome
Klain et al., J Nutr 1977
:
Compared to the fed controls,
glucagon reduced hepatic fatty acid synthesis and acetyl
CoA carboxylase activity by 62 % and 65 % in fed rats, and by 51 % and 48 %, respectively, in refed rats
Berglund et al., Am J Physiol Endocrinol Metab 2010
:
It blunted
glucagon stimulated
acetyl-CoA carboxylase phosphorylation, a downstream target of AMPK, and accentuated PPARa and FGF21 expression
Swenson et al., J Biol Chem 1985
:
Mechanism of
glucagon inhibition of liver
acetyl-CoA carboxylase ... The observation of these
effects of
glucagon on
acetyl-CoA carboxylase activity is absolutely dependent upon the minimization of proteolytic degradation of the enzyme after cell lysis
McGarry et al., Diabetes 1980
:
At low concentrations of fatty acid the
effect of
glucagon was to abolish
malonyl-CoA synthesis and lipogenesis and to produce a marked stimulation of fatty acid oxidation and ketogenesis