Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
MAPK1
→
AGER
(increases, AGER Activity, MAPK1 Activity)
Evidence: In addition to NF-?B, among the known pathways that can be activated by RAGE are phosphoinositide 3-kinases (PI3K)/Akt (also termed as protein kinase B), and mitogen-activated protein kinase members (MAPKs) (52,53). The latter group includes Jun-N-terminal kinase (JNK), p38, and extracellular signal-regulated kinases (ERK) (54,55) (Figure 2).
OpenBEL Selventa BEL large corpus:
MAPK1
→
AGER
(increases, AGER Activity, MAPK1 Activity)
Evidence: CML-modified albumin produced rapid transient activation of tyrosine phosphorylation, extracellular signal-regulated kinase 1 and 2, and p38 mitogen-activated protein kinase (MAPK)