Gene interactions and pathways from curated databases and text-mining

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AGER — MAPK1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK1 → AGER (increases, AGER Activity, MAPK1 Activity)
    Evidence: In addition to NF-?B, among the known pathways that can be activated by RAGE are phosphoinositide 3-kinases (PI3K)/Akt (also termed as protein kinase B), and mitogen-activated protein kinase members (MAPKs) (52,53). The latter group includes Jun-N-terminal kinase (JNK), p38, and extracellular signal-regulated kinases (ERK) (54,55) (Figure 2).
  • OpenBEL Selventa BEL large corpus: MAPK1 → AGER (increases, AGER Activity, MAPK1 Activity)
    Evidence: CML-modified albumin produced rapid transient activation of tyrosine phosphorylation, extracellular signal-regulated kinase 1 and 2, and p38 mitogen-activated protein kinase (MAPK)
  • Reactome Reaction: MAPK1 → AGER (indirect_complex) Ishihara et al., FEBS Lett 2003
  • Reactome Reaction: MAPK1 → AGER (reaction) Ishihara et al., FEBS Lett 2003