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CXCR4 — VEGFA

Text-mined interactions from Literome

Bachelder et al., Cancer Res 2002 (Breast Neoplasms...) : VEGF regulates expression of the chemokine receptor CXCR4 , and this VEGF target is needed for invasion but not for cell survival ... CXCR4 mediates migration of breast carcinoma cells toward stromal derived factor-1, and this migration is dependent on autocrine VEGF
Salcedo et al., Blood 2003 : Stimulation of vascular endothelial growth factor ( VEGF ) and basic fibroblast growth factor (bFGF) increases the expression of CXCR4 on endothelial cells, rendering these cells more responsive to stromal derived factor 1 (SDF-1), an angiogenic CXC chemokine and unique ligand for CXCR4
Salmaggi et al., J Neurooncol 2004 (Brain Neoplasms...) : CXCR4 was found in cells lines and primary cultures from malignant gliomas as well as in endothelial cells and was increased by vascular endothelial growth factor and basic fibroblast growth factor (bFGF)
Yang et al., Biochem Biophys Res Commun 2005 (Glioma...) : Activation of chemokine receptor CXCR4 in malignant glioma cells promotes the production of vascular endothelial growth factor ... In this study, we investigated the role of CXCR4 in the production of angiogenic factor, vascular endothelial growth factor ( VEGF ), in various human glioma cells from astrocytic origin ... Our results suggest that CXCR4 may contribute to the high level of VEGF produced by malignant glioma cells and thus constitute a therapeutic target for antiangiogenesis strategy
Oda et al., Mod Pathol 2006 (Bone Neoplasms...) : It has also been demonstrated that VEGF regulates both the expression of CXCR4 and invasiveness in breast cancer cell lines
Zagzag et al., Lab Invest 2006 (Anoxia...) : Next, we tested the in vitro effect of hypoxia and vascular endothelial growth factor ( VEGF ) on the expression of CXCR4 in glioma cell lines and in human brain microvascular endothelial cells ( HBMECs )
Ping et al., J Neurooncol 2007 (Brain Neoplasms...) : The anti-cancer compound Nordy inhibits CXCR4 mediated production of IL-8 and VEGF by malignant human glioma cells
Yu et al., Biochem Biophys Res Commun 2007 : Additionally, hypoxia and VEGF , the factors affecting microvascular, regulate the expression level of CXCR4 in HRMECs, respectively, which have synergistic, additive effect in the HRMECs
Ping et al., Zhonghua Bing Li Xue Za Zhi 2007 (Brain Neoplasms...) : Activation of CXCR4 on glioma stem cells induced calcium mobilization and increased VEGF and IL-8 protein secretion
Liang et al., Biochem Biophys Res Commun 2007 (Breast Neoplasms) : Here, we investigated whether CXCR4 induces the expression of VEGF through the PI3K/Akt pathway
Schutyser et al., Eur Cytokine Netw 2007 (Anoxia...) : CXCR4 mRNA expression was not affected by VEGF , GM-CSF, IL-1beta or various basal membrane matrix components, but was significantly up-regulated after serum starvation and/or hypoxic treatment of the microvascular endothelial cells
Maderna et al., Cancer Biol Ther 2007 (Brain Neoplasms...) : VEGF expression upregulates CXCR4 on endothelial cells, binding the chemokine SDF1/CXCL12 ( Stromal Derived Factor ) that has a role on angiogenesis and chemotaxis of endothelial cells ; PDGF ( platelet derived growth factor ) and PDGFRbeta are also crucial by increasing the expression of VEGF
Bian et al., Neurosurgery 2007 (Brain Neoplasms...) : Activation of CXCR4 induced tumor cell chemotaxis and increased production of vascular endothelial growth factor
Zagzag et al., Am J Pathol 2008 (Brain Neoplasms...) : Hypoxia- and vascular endothelial growth factor induced stromal cell derived factor-1alpha/CXCR4 expression in glioblastomas : one plausible explanation of Scherer 's structures
Kim et al., Leukemia & lymphoma 2009 (Anoxia...) : Tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta1 ( TGF-beta1 ), and vascular endothelial growth factor ( VEGF ) enhanced CXCR4 expression in RPMI8226 cells
Carretero-Ortega et al., Mol Pharmacol 2010 : We also demonstrate that in endothelial cells, VEGF promotes an increase in the expression of endogenous P-Rex1 and the SDF-1 receptor CXCR4 , In addition, VEGF pretreated cells show an increased migratory and angiogenic response to SDF-1, suggesting that VEGF stimulation can complement SDF-1/CXCR4 signaling to induce angiogenesis
Ahmadbeigi et al., Cell Biol Int 2010 : It was also revealed that VEGF increased surface expression and mRNA level of CXCR4 in USSCs, while IGF-1 decreased its expression
Sun et al., Mol Cancer Ther 2013 : CXCR4 expression, analyzed by real-time PCR and Western blot, was increased in human chondrosarcoma cell line JJ compared with normal chondrocytes and was further increased in JJ by hypoxia ( 2 % O2 ), vascular endothelial growth factor A ( VEGFA ; 10 ng/mL ), and in xenograft tumors in nude mice