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CD55 — VEGFA
Text-mined interactions from Literome
Mason et al., Arthritis Rheum 2001
(Neovascularization, Pathologic) :
Because vascular endothelial growth factor ( VEGF ) is cytoprotective to endothelium and is expressed at sites of chronic inflammation, we hypothesized that
VEGF may
induce DAF expression during inflammatory angiogenesis ... Although VEGF induced EC proliferation was inhibited by both p38 and p42/44 mitogen activated protein kinase ( MAPK ) antagonists,
DAF up-regulation in
response to
VEGF was only sensitive to inhibition of p38 MAPK ... The
up-regulation of
DAF expression by
VEGF may represent an important mechanism for the protection of EC from complement mediated injury during angiogenesis in inflammatory rheumatic diseases
Mason et al., Am J Physiol Cell Physiol 2002
:
In contrast, although PKC antagonists inhibited
VEGF induced
DAF expression, bFGF induced DAF was unaffected ... Investigation of mitogen activated kinase ( MAPK ) pathways also revealed differences, with bFGF induced
DAF dependent on p44/42 and p38 MAPK and
VEGF requiring activation of p38 MAPK alone
Morgan et al., Tissue Antigens 2002
(Colorectal Neoplasms...) :
This study investigated the
effects of
VEGF on CD55 deposition into matrix and the release of
CD55 by metalloproteinases ... In contrast to inflammatory cytokines,
CD55 was
up-regulated by
VEGF at the cell surface and within the extracellular matrix ( ECM )
Mason et al., J Biol Chem 2004
:
Use of PKC agonists and isozyme-specific pseudosubstrate peptide antagonists suggested a role for PKCalpha and -epsilon in
VEGF mediated
DAF up-regulation ... This was confirmed by transfection of ECs with PKCalpha and -epsilon dominant negative constructs, which in combination completely abrogated
induction of
DAF by
VEGF ... The widely used immunosuppressive drug cyclosporin A ( CsA ) inhibited
DAF induction by
VEGF in a dose dependent manner ... The
VEGF induced
DAF expression was functionally effective, significantly reducing complement mediated EC lysis, and this cytoprotective effect was reversed by CsA