Gene interactions and pathways from curated databases and text-mining

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CD79A — TNFSF13

Text-mined interactions from Literome

Castigli et al., Proc Natl Acad Sci U S A 2004 : APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM ( + ) IgD ( + ) sorted B cells
Castigli et al., Nat Genet 2005 (Common Variable Immunodeficiency...) : B cells from individuals with TACI mutations expressed TACI but did not produce IgG and IgA in response to the TACI ligand APRIL , probably reflecting impaired isotype switching
Castigli et al., J Allergy Clin Immunol 2006 (Common Variable Immunodeficiency...) : B cells from individuals with TACI mutations did not produce IgG and IgA in response to the TACI ligand a proliferation inducing ligand (APRIL) , probably reflecting impaired isotype switching
Sakurai et al., Blood 2007 : Experiments using TACI siRNA into B cells indicated that TACI positively regulated APRIL induced IgA production in collaboration with heparan sulfate proteoglycans (HSPG)
Jin et al., Int J Mol Med 2008 (Common Variable Immunodeficiency...) : B cells from individuals with TACI mutations do not produce IgG and IgA in response to the TACI ligand a proliferation inducing ligand (APRIL) which probably suggests impaired isotype switching
Kanswal et al., J Immunol 2008 : More importantly, TACI ligands BAFF or APRIL were unable to induce IgA/IgG/IgM secretion from newborn B lymphocytes
Kimberley et al., FASEB J 2009 : In contrast to previous reports, we found that APRIL alone is sufficient to costimulate B-cell proliferation and drive IgA production and does not require artificial antibody cross linking
Fabris et al., Ann N Y Acad Sci 2009 (Celiac Disease...) : Because APRIL promotes IgA production, its overexpression may represent a physiological mechanism of compensation
Tezuka et al., Immunity 2011 : IgA production was dependent on APRIL and BAFF production by pDCs