◀ Back to IL10

IL10 — MMP2

Text-mined interactions from Literome

Stearns et al., Clin Cancer Res 1999 (Neoplasm Metastasis...) : ELISAs further showed that TGF-beta1 expression induced matrix metalloproteinases-2 (MMP-2) expression, whereas IL-10 down-regulated MMP-2 expression while up regulating TIMP-1 in the transfected cells
Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
John et al., Exp Lung Res 2002 (Pneumonia, Bacterial...) : Increased production of matrix metalloproteinase-2 in alveolar macrophages and regulation by interleukin-10 in patients with acute pulmonary sarcoidosis ... The endogenous production of IL-10 in AM of patients with sarcoidosis and the MMP downregulation by exogenous IL-10 suggest an involvement of IL-10 in MMP regulation
Stearns et al., Clin Cancer Res 2003 (Prostatic Neoplasms) : Interleukin 10 blocks matrix metalloproteinase-2 and membrane type 1-matrix metalloproteinase synthesis in primary human prostate tumor lines ... In this paper, we showed that IL-10 activation of the IL-10 receptor blocked MMP-2 and membrane type 1 (MT1) -MMP transcription and protein synthesis in nonimmortalized primary human prostate cell strains ( i.e., HPCA-10a and HPCA-10c ) derived from high-grade cancer ... Northern blots, Western blots, and ELISAs showed that IL-10 suppressed IGF-I induction of MMP-2 and MT1-MMP mRNA synthesis in these cell strains ( P < 0.001 ) ... The data show that IL-10 blocks IGF-I activation of MMP-2 and MT1-MMP mRNA expression and protein synthesis in primary prostate cell strains
An et al., Zhonghua Nei Ke Za Zhi 2003 (Lung Diseases, Obstructive...) : The expression and enzymatic activity of MMP-2 and MMP-9 in lung tissue, the counts of total leukocytes and neutrophils and the level of TNFalpha in BALF were significantly elevated, but the level of IL-10 in BALF was significantly reduced in model group compared with those in control group ( P < 0.01, respectively )
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Stearns et al., Mol Cancer Res 2004 (Prostatic Neoplasms) : Interleukin-10 induced activating transcription factor 3 transcriptional suppression of matrix metalloproteinase-2 gene expression in human prostate CPTX-1532 Cells ... We investigated the effects of interleukin (IL)-10 on MMP-2 expression in CPTX-1532 human prostate tumor cells ... Our results demonstrate that IL-10 significantly inhibited MMP-2 transcription and protein expression induced by a phorbol ester, phorbol 12-myristate 13-acetate ... The inhibitory effects of IL-10 on MMP-2 expression correlated with the suppression of MMP-2 promoter activity ... Immunoblot assays of activating transcription factor (ATF) 3 immunoprecipitates with tyrosine specific antibodies revealed that IL-10 stimulated tyrosine phosphorylation of ATF3 to activate binding to the CREB domain and suppress MMP-2 expression ... Finally, reconstitution of ATF3 successfully restored the inhibitory effects of IL-10 on MMP-2 gene expression
Perianayagam et al., Eur J Clin Invest 2005 (Uremia) : We hypothesized that previously reported defective synthesis of IL-10 by immunocompetent cells exposed to a uraemic milieu may be due to impaired mitochondrial membrane potential ( MMP )
Chou et al., Acta Pharmacol Sin 2006 (Liver Cirrhosis, Experimental) : Furthermore, IL-10 significantly inhibited matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of matrix metalloproteinase ( TIMP ) activation after CCl4 intoxication
Li et al., Zhejiang Da Xue Xue Bao Yi Xue Ban 2007 : For other cytokines, astragalus polysaccharides induced a 104.9 fold higher expression of MMP2 , while astragalosides induced a 550.65 fold higher expression of IL-10
Hu et al., Zhonghua Xin Xue Guan Bing Za Zhi 2008 (Myocardial Infarction...) : We investigated the in vivo effects of recombinant adenovirus associated virus type-2 ( AAV-2 ) mediated interleukin-10 (IL-10) gene transfer on the expression of matrix metalloproteinase (MMP)-2 , 9, tissue inhibitor of metalloproteinase ( TIMP ) -1, collagen type I and type III in a rat acute myocardial infarction model ... In vivo myocardial IL-10 transfer reduced myocardial MMP and collagen expression and increasing the TIMP expression
Coussens et al., Immunology 2009 (Tuberculosis) : We therefore determined the effects of 1alpha,25 ( OH ) ( 2 ) D ( 3 ) on expression, secretion and activity of a number of MMP and TIMP in M. tuberculosis infected human leucocytes ; we also investigated the effect of 1alpha,25 ( OH ) ( 2 ) D ( 3 ) on the secretion of interleukin-10 (IL-10) and prostaglandin E ( 2 ) ( PGE ( 2 ) ), both transcriptional regulators of MMP expression
Salamonsen et al., Hum Reprod 1996 : Progesterone withdrawal from stromal cell cultures ( for the final 4 days of a 10 day culture ) increased the release of all four enzymes : all but MMP-2 were also stimulated by interleukin-1 or tumour necrosis factor alpha added to short-term stromal cultures
Stearns et al., Invasion Metastasis 1997 (Bone Neoplasms...) : IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2/MMP-9 expression ... However IL-10 may inhibit the production of matrix metalloproteases ( MMP ) and prevent the establishment of metastasis
Wagner et al., J Neurooncol 1998 (Brain Neoplasms...) : In all but one cell line no enhancement of MMP expression by IL-10 was detected