Yang et al., Am J Physiol Gastrointest Liver Physiol 2007
:
Intestinal EC are a rich source of IL-7 , a critical factor to support the maintenance of several lymphoid tissues, and TPN results in marked EC changes ... On this basis, we hypothesized that TPN would diminish EC-derived IL-7 expression and that this would contribute to the observed changes in the IEL population
Yang et al., Ann Surg 2008
:
Previous work shows that TPN results in a loss of intestinal epithelial cell derived interleukin-7 (IL-7) , and this loss may play an important role in development of such TPN associated IEL changes