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CREBBP — JUN

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: JUN → CREBBP (directlyIncreases, CREBBP Activity)
  Evidence: Fig.1- shows proteins that interact with CBP/300 Transciptional activators= STAT1, (already). SF1, TAL1, p73, Mdm2, HIF2?, ETS1, RXR, p65, Pit1 (POU1F1), HNF4, Stat2, EBNA2 (virus), HPV E2?, BRCA1, p45/NF-E2, c-JUN, c-myb, Tax?, Sap1, YY1, SREBP, ATF-1, ATF-4, Cubitus interuptusm GII3?, vIRF?, JMY, dMAD?, Py LT?, HPV E6, CIITA, Tat(HIV), SF-1, E2F, Ets-1, junB, C/EBPb, (already) GATA-1, Neuro D, Microphthalmia, E1A, Twist, p53 (already), Myo D, pp90 RSK, SMAD (already), ATF-2, c-Fos, SC40?, Lar...
• BioCarta the information processing pathway at the ifn beta enhancer: IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: IFN-beta nucleosome complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → TAFs/TF2A/TBP/TF2F/TF2B/TF2H/TF2E/RNA POL II complex (GTF2A1-NR3C1-GTF2F1-GTF2B-GTF3A-GTF2E1-POLR2A) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → histone transacetylase (CREBBP) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: histone transacetylase (CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF complex (ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: hSWI/SNF complex (SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta the information processing pathway at the ifn beta enhancer: RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP) → RELA/p50/ATF-2/IRF/c-JUN/HMG1/PCAF/CBP/hSWI/SNF complex (RELA-ATF2-IRF5_IRF1_IRF3_IRF6_IRF7_IRF4_IRF2-JUN-HMGB1-PCAF-CREBBP-SMARCA4-SMARCD1-ARID1A-SMARCC1-SMARCC2-SMARCB1-SMARCE1-ACTB) (modification, collaborate)
  
• BioCarta mechanism of gene regulation by peroxisome proliferators via ppara: PPAR-alpha/Transcription factors complex (PPARA-JUN_RELA_SP1) → PPAR-alpha/PPAR ligands/RXR/Co-Activators complex (PPARA-RXRA-CITED2_NCOA1_PPARGC1A_CREBBP_NRIP1_EP300_PPARBP_SRA1) (transcription, inhibits)
  
• NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer)/JUN/Cbp complex (STAT4-JUN-CREBBP) → IL2R alpha (IL2RA) (transcription, activates) O'Sullivan et al., J Biol Chem 2004*
  Evidence: assay
• NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer)/JUN/Cbp complex (STAT4-JUN-CREBBP) → STAT4 (dimer) complex (STAT4) (modification, collaborate)
  O'Sullivan et al., J Biol Chem 2004*
  Evidence: physical interaction
• NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer)/JUN/Cbp complex (STAT4-JUN-CREBBP) → JUN/Cbp complex (JUN-CREBBP) (modification, collaborate)
  O'Sullivan et al., J Biol Chem 2004*
  Evidence: physical interaction
• NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer) complex (STAT4) → JUN/Cbp complex (JUN-CREBBP) (modification, collaborate)
  O'Sullivan et al., J Biol Chem 2004*
  Evidence: physical interaction
• NCI Pathway Database FOXA1 transcription factor network: nucleus (EP300/CREBBP) → AP1 complex (FOS-JUN) (transcription, activates) Eeckhoute et al., Genes Dev 2006
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database HIF-1-alpha transcription factor network: AP1 complex (FOS-JUN) → nucleus (EP300/CREBBP) (transcription, activates) Yamashita et al., J Biol Chem 2001
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CREBBP — JUN (physical association, affinity chromatography technology) Johnson et al., J Biol Chem 2007*
• IRef Biogrid Interaction: CREBBP — JUN (colocalization, imaging technique) Yamaguchi et al., J Biol Chem 2005*
• IRef Biogrid Interaction: CREBBP — JUN (direct interaction, pull down) Sano et al., J Biol Chem 1998*
• IRef Biogrid Interaction: CREBBP — JUN (physical association, affinity chromatography technology) Sano et al., J Biol Chem 1998*
• IRef Biogrid Interaction: CREBBP — JUN (direct interaction, pull down) Merika et al., Mol Cell 1998*
• IRef Biogrid Interaction: CREBBP — JUN (direct interaction, pull down) Duyndam et al., Oncogene 1999*
• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
• IRef Hprd Interaction: CREBBP — JUN (in vitro) Bossis et al., Mol Cell Biol 2005*, Benbrook et al., Oncogene 1990*, Sano et al., J Biol Chem 1998*
• IRef Hprd Interaction: CREBBP — JUN (in vivo) Bossis et al., Mol Cell Biol 2005*, Benbrook et al., Oncogene 1990*, Sano et al., J Biol Chem 1998*
• IRef Innatedb Interaction: CREBBP — JUN (unknown, -) Merika et al., Mol Cell 1998*
• IRef Innatedb Interaction: CREBBP — JUN (unknown, -) Johnson et al., J Biol Chem 2007*
• IRef Ophid Interaction: CREBBP — JUN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

O'Connor et al., J Virol 1996 : We also provide data demonstrating that YY1 can bind the transcriptional coactivator CREB binding protein and propose a potentially novel mechanism by which YY1 represses AP-1 activity as a result of this YY1-CREB binding protein interaction
Lee et al., Cell Growth Differ 1997 (Carcinoma, Non-Small-Cell Lung...) : Furthermore, the inhibitory effect of t-RA on AP-1 transcriptional activity was not restored in tumorigenic 11701 cells by transfection of c-fos, silencing mediator for retinoid and thyroid hormone receptors, Jun activation domain binding protein 1, or CREB binding protein , suggesting the involvement of other transcriptional coregulators in this retinoid signaling defect
Caelles et al., Genes Dev 1997 : This phosphorylation is mediated by the Jun amino-terminal kinase (JNK) and required to recruit the transcriptional coactivator CREB binding protein (CBP)