◀ Back to MDM2
MDM2 — RPS27
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
RPS27
—
MDM2
(physical association, affinity chromatography technology)
Xiong et al., Oncogene 2011*
-
IRef Biogrid Interaction:
RPS27
—
MDM2
(direct interaction, pull down)
Xiong et al., Oncogene 2011*
-
IRef Intact Interaction:
MDM2
—
RPS27
(direct interaction, pull down)
Xiong et al., Oncogene 2011*
-
IRef Intact Interaction:
MDM2
—
RPS27
(physical association, anti bait coimmunoprecipitation)
Xiong et al., Oncogene 2011*
-
IRef Intact Interaction:
MDM2
—
RPS27
(physical association, anti tag coimmunoprecipitation)
Xiong et al., Oncogene 2011*
Text-mined interactions from Literome
Xiong et al., Oncogene 2011
:
Several
ribosomal proteins regulate p53 function by modulating
MDM2
Daftuar et al., PloS one 2013
:
Relevantly, a number of
RPs have been shown to bind to MDM2 and
inhibit MDM2 E3 ligase activity, leading to p53 stabilization and cell cycle arrest, thus revealing a RP-Mdm2-p53 signaling pathway that is critical for ribosome biogenesis surveillance