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IL6 — PRKAB2
Text-mined interactions from Literome
MacDonald et al., J Appl Physiol 2003
:
The present data are compatible with a
role for
AMPK in
IL-6 release during exercise or a role for IL-6 in activating AMPK
Giri et al., J Neurosci 2004
(Inflammation) :
A pharmacological activator of
AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR )
inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha,
interleukin-1beta , and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages ... A pharmacological activator of
AMPK , 5-amino-4-imidazole carboxamide riboside ( AICAR )
inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta, and
interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Kelly et al., Biochem Biophys Res Commun 2004
:
The results indicate that
IL-6 can
activate AMPK in muscle and adipose tissue, and that this contributes to, but does not fully account for, the increase in AMPK activity in these tissues in response to exercise
Du et al., Biochem Biophys Res Commun 2005
:
To determine whether
AMPK activation will
promote IL-6 production, cardiac fibroblasts ( CFs ) from mice were incubated with AMPK activator, 5-aminoimidazole-4-carboxamide-1-4-ribofuranoside ( AICAR ) ... In conclusion,
AMPK activation
promoted IL-6 production in CFs via p38 MAPK dependent pathway
Carey et al., Diabetes 2006
(Hyperinsulinism) :
Furthermore,
IL-6 rapidly and markedly
increased AMP activated protein kinase (AMPK)
Weigert et al., Am J Physiol Cell Physiol 2007
:
Because IL-6 has been shown to activate AMP activated kinase (AMPK), we studied whether, in turn, activated
AMPK induces
IL-6 expression
Baumann et al., Exp Cell Res 2007
(Multiple Myeloma) :
Activation of
AMPK inhibited basal extracellular signal regulated kinase ( ERK ), mammalian target of rapamycin (mTOR) and P70S6 kinase ( P70S6K ) as well as AKT phosphorylation, and
blocked IL-6 , IGF-1, and HS-5 stromal cell conditioned medium induced increase of cell growth
Pedersen et al., Biochem Soc Trans 2007
(Disease...) :
Furthermore,
IL-6 rapidly and markedly
increases AMPK ( AMP activated protein kinase ) and the metabolic effects of IL-6 were abrogated in AMPK dominant negative infected cells
Yuen et al., Diabetes 2009
:
The
effect of
IL-6 with and without insulin on
AMPK , insulin, and eNOS signaling in and nitric oxide ( NO ) release from human aortic endothelial cells ( HAECs ) was examined ...
IL-6 blunted increases in insulin signaling, eNOS phosphorylation ( Ser1177 ), and NO production and
reduced phosphorylation of
AMPK in HAEC in vitro and capillary recruitment in vivo
Kelly et al., Diabetes 2009
:
Interleukin-6 (IL-6) directly
activates AMP activated protein kinase (AMPK) in vivo and in vitro ; however, the mechanism by which it does so is unknown ...
AMPK activation by
IL-6 coincided temporally with a nearly threefold increase in the AMP : ATP ratio in the EDL ... The
effects of
IL-6 on both
AMPK activity and energy state were inhibited by coincubation with propranolol, suggesting involvement of beta-adrenergic signaling ... In keeping with this notion,
IL-6 concurrently induced a transient increase in cAMP, and its ability to activate
AMPK was
blocked by the adenyl cyclase inhibitor 2'5'-dideoxyadenosine
Łabuzek et al., Neurotoxicology 2010
:
Furthermore, we found that the effects of AICAR on
IL-6 and TNF-alpha ( 12, 24h ) release and on the expression of iNOS and NF-kappaB p65 are not
AMPK dependent because the pre-treatment of LPS activated microglia with compound C ( a pharmacological inhibitor of AMPK ) did not reverse the effect of AICAR
Fan et al., J Cell Physiol 2011
:
Inhibitors of
AMPK ( araA ), p38MAPK ( SB202190 ), and ERK1/2 ( PD98059 and U0126 ) but not JNK ( SP600125 )
suppressed gAd induced
IL-6 production
Łabuzek et al., Pharmacol Rep 2010
:
Furthermore, the effects of metformin on the release of IL-1ß,
IL-6 , IL-10, TGF-ß, NO, and ROS as well as on the expression of arginase I, iNOS, NF-?B p65 and PGC-1a were not
AMPK dependent , because pretreatment of LPS activated microglia with compound C, a pharmacological inhibitor of AMPK, did not reverse the effect of metformin
Adser et al., Acta Physiol (Oxf) 2011
:
The aim of this study was to test the hypothesis that interleukin (IL)-6 plays a role in exercise induced peroxisome proliferator activated receptor ? co-activator ( PGC ) -1a and tumor necrosis factor (TNF)-a mRNA responses in skeletal muscle and to examine the potential
IL-6 mediated
AMP activated protein kinase (AMPK) regulation in these responses ... In conclusion,
IL-6 affects exercise induced glycogen use,
AMPK signalling and TNF-a mRNA responses in mouse skeletal muscle
Li et al., Basic Res Cardiol 2011
:
AMPK activation by
IL-6 appears to be dispensable for the mitochondrial biogenic responses to chronic treadmill exercise
Kato et al., Life Sci 2012
:
In the present study, we investigated the
involvement of
AMP activated protein kinase (AMPK) , a regulator of energy metabolism, in the PDGF-BB stimulated
IL-6 synthesis in MC3T3-E1 cells ... These results strongly suggest that
AMPK positively
regulates PDGF-BB stimulated
IL-6 synthesis via the MAP kinases in osteoblasts
Serrano-Marco et al., Diabetologia 2012
(Insulin Resistance) :
Furthermore, drug treatment prevented the
IL-6 dependent reduction in phosphorylated
AMP activated protein kinase (AMPK) , a kinase reported to inhibit STAT3 phosphorylation on Tyr7°5
Fitzgerald et al., PloS one 2012
(Carcinoma, Renal Cell...) :
Finally, we have characterized that enhanced levels of IL-6 and IL-8 result in RCC cell invasion and that activation of
AMPK reduces Nox4 expression,
IL-6 and IL-8 production, and RCC cell invasion
Kato et al., Cell Signal 2012
:
In the present study, we investigated the
role of
AMPK in the interleukin-1 (IL-1) stimulated
IL-6 synthesis in osteoblast-like MC3T3-E1 cells ... These results strongly suggest that
AMPK negatively
regulates IL-1 stimulated
IL-6 synthesis through the I?B/NF-?B pathway in osteoblasts
Tokuda et al., J Mol Endocrinol 2012
:
In this study, we investigated the
involvement of
AMP activated protein kinase (AMPK) , a regulator of energy metabolism, in thrombin stimulated
IL6 synthesis in MC3T3-E1 cells ... These results strongly suggest that
AMPK regulates thrombin stimulated
IL6 synthesis via p44/p42 MAP kinase and p38 MAP kinase in osteoblasts
Wan et al., PloS one 2012
:
The
activation of
AMPK by
IL-6 was independent of increases in lipolysis
Wan et al., PloS one 2012
(Insulin Resistance) :
We have shown that
IL-6 activates
AMPK , a mediator of mitochondrial biogenesis, in adipose tissue ; however, IL-6 ( -/- ) mice fed a high fat diet have been reported to develop insulin resistance
White et al., Am J Physiol Endocrinol Metab 2013
(Cachexia...) :
IL-6 suppression of mTOR activity was
dependent on
AMPK activation and independent of STAT signaling in myotubes
Kondo et al., Arch Biochem Biophys 2013
:
We previously reported that interleukin 1 (IL-1) stimulates the synthesis of interleukin 6 (IL-6) through activation of ERK and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that
AMP activated protein kinase (AMPK) negatively
regulates the IL-1 induced
IL-6 synthesis through I?B/NF-?B pathway
Nerstedt et al., Mol Cell Endocrinol 2013
:
Further studies using the human hepatocellular carcinoma cell line HepG2 suggest that
AMPK inhibits
IL-6 signalling by repressing IL-6 stimulated phosphorylation of several downstream components of the pathway such as Janus kinase 1 (JAK1), SH2-domain containing protein tyrosine phosphatase 2 ( SHP2 ) and signal transducer and activator of transcription 3 ( STAT3 )
Kuroyanagi et al., Biochimie 2013
:
We previously reported that interleukin-1 (IL-1), a potent bone resorptive cytokine, stimulates the synthesis of interleukin-6 (IL-6) via activation of p44/p42 mitogen activated protein ( MAP ) kinase and p38 MAP kinase in osteoblast-like MC3T3-E1 cells, and that
AMP activated protein kinase (AMPK) negatively
regulates the IL-1 induced
IL-6 synthesis through the inhibitor of ?B ( I?B ) /nuclear factor-?B ( NF-?B ) pathway