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IL6 — PGP

Text-mined interactions from Literome

Hartmann et al., Int Immunopharmacol 2001 : These findings indicate that IL-6 plays a principal role in the downregulation of PGP that is observed in the livers of mice during an inflammatory response
Gargir et al., J Leukoc Biol 2001 : By itself, lipoteichoic acid (LTA) obtained from S. pyogenes, S. aureus, or E. hirae poorly stimulated cytokine production by macrophages, whereas in the presence of anti-polyglycerol phosphate (PGP) , the cells secreted significant amounts of IL-6
Bonhomme-Faivre et al., Anticancer Drugs 2002 : Based on the premise that Taxol pharmacokinetic parameters could be modified as a result of diminished P-gp expression induced by recombinant interleukin ( rIL ) -2 and that this might elicit an interaction between the two drugs, we evaluated the pharmacokinetics of a novel strategy combining i.p. immunotherapy with rIL-2 and a cytotoxic agent, Taxol
Ronaldson et al., Mol Pharmacol 2006 (Inflammation) : P-gp protein expression was increased in astrocyte cultures exposed to TNF-alpha ( 2.9-fold ) or IL-1beta ( 1.6-fold ) but was decreased profoundly in the presence of IL-6 ( 8.9-fold ), suggesting that IL-6 is primarily involved in modulating P-gp expression