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IL6 — MSH3
Text-mined interactions from Literome
Lindberg et al., Neurotox Res 2005
:
Neither IFN-gamma nor
alpha-MSH affected the Abeta induced secretion of IL-6, but
resulted in a dose dependent increase in basal
IL-6 release ... Agouti, the endogenous antagonist of MCR1 and 4, further increased the
alpha-MSH induced secretion of
IL-6
Colombo et al., Shock 2007
(Inflammation...) :
Bleomycin induced expression of proinflammatory and profibrotic factors (
interleukin 6 , tumor necrosis factor-alpha, transforming growth factor-beta1, and inducible nitric oxide synthase ) and chemokines ( chemokine [C-C motif] ligand 2 and chemokine [C-C motif] ligand 5 ) was likewise significantly
reduced by
NDP-alpha-MSH
Jun et al., J Mol Endocrinol 2010
:
Specific inhibition of MC2R and MC5R expression with short interfering Mc2r and Mc5r RNAs significantly attenuated the
alpha-MSH induced increase of intracellular cAMP and both the level of Il6 mRNA and secretion of
IL6 in 3T3-L1 adipocytes ... Finally, when injected into mouse tail vein,
alpha-MSH dramatically
increased the
Il6 transcript levels in epididymal fat pads
Biondi et al., Mol Hum Reprod 2010
:
In addition,
interleukin-1beta and estrone are able to
enhance MRP1 gene expression and influence extracellular cAMP concentration
Minutoli et al., Endocrinology 2011
(Inflammation...) :
NDP-a-MSH inhibited
IL-6 and TNF-a expression, decreased histological damage, and increased neural efferent activity
Spaccapelo et al., Eur J Pharmacol 2013
(Brain Ischemia...) :
NDP-a-MSH increased hippocampus dentate gyrus ( DG ) expression of Wnt-3A, ß-catenin, Sonic hedgehog (Shh), Zif268,
interleukin-10 (IL-10) and doublecortin ( DCX ), as detected at days 3, 6 and 10 after the ischemic insult
Delgado et al., J Leukoc Biol 1998
:
We tested
effects of
alpha-MSH ( 1-13 ), alpha-MSH ( 11-13 ), and ACTH ( 1-24 ) on production of tumor necrosis factor alpha (TNF-alpha),
interleukin-6 (IL-6) , and nitric oxide ( NO ) in a cultured murine microglial cell line ( N9 ) stimulated with lipopolysaccharide (LPS) plus interferon gamma (IFN-gamma)
Huang et al., Am J Physiol 1998
(Fever) :
Intraperitoneal
alpha-MSH also
suppressed the LPS induced rise in plasma
IL-6 , ACTH, and corticosterone ( CS ) levels ... Intracerebroventricular injection of SHU-9119, a potent melanocortin-4 receptor (MC4-R)/MC3-R antagonist, completely blocked the antipyretic effect of intraperitoneal alpha-MSH during the first 4 h after LPS but had no effect on
alpha-MSH induced suppression of LPS stimulated plasma
IL-6 and CS levels