Gene interactions and pathways from curated databases and text-mining

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AGTR1 — IL6

Text-mined interactions from Literome

Street et al., J Endocrinol 2003 : Both IGFBP-2 and IGFBP-4 were reduced by IL-1beta and IL-6 in combination at 1 and 10 ng/ml ( P < 0.05 )
Schieffer et al., J Am Coll Cardiol 2004 (Coronary Artery Disease...) : Angiotensin converting enzyme (ACE) inhibition and angiotensin II type 1 receptor (AT1) blockade reduced serum MMP-9 protein/activity to a similar extent, and only AT1 blockade reduced hsCRP, IL-6 , and platelet aggregation in patients with CAD
Kandalam et al., Regul Pept 2010 : Our study showed for the first time that Ang II induced JAK2/STAT3 phosphorylation and IL-6 secretion through activation of the Ang II AT(1) receptor in brainstem astrocytes
Nakamura et al., Eur J Oral Sci 2011 (Gingivitis) : Therefore, in the present study the expression of the angiotensin II type 1 receptor (AT1R) was investigated in inflamed human gingival tissue, and the possible involvement of the AT1R in interleukin-1ß (IL-1ß) induced interleukin-6 (IL-6) production by cultured human gingival fibroblasts ( HGFs ) was also studied ... The data suggest that the AT1R may be involved in the regulation of gingival inflammation by modulating IL-1ß induced IL-6 production in HGFs
Franchimont et al., Endocrinology 1997 : IL-6 did not modify IGF-I messenger RNA ( mRNA ) levels, but when tested in the presence of IL-6sR, IL-6 at 1 to 100 ng/ml increased IGF-I transcripts by up to 3.2-fold after 24 h. IL-6sR caused a small increase in IGF-I mRNA levels when tested alone