◀ Back to TRAF1

IKBKB — TRAF1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF1 — IKBKB (direct interaction, two hybrid) Sughra et al., PloS one 2010*
• IRef Biogrid Interaction: TRAF1 — IKBKB (direct interaction, fluorescent resonance energy transfer) Sughra et al., PloS one 2010*
• IRef Biogrid Interaction: TRAF1 — IKBKB (physical association, affinity chromatography technology) Sughra et al., PloS one 2010*
• IRef Biogrid Interaction: TRAF1 — IKBKB (direct interaction, two hybrid) Henkler et al., J Biol Chem 2003*

Text-mined interactions from Literome

Henkler et al., J Biol Chem 2003 : Importantly, the caspase generated TRAF1-fragment , but not TRAF1 itself inhibited IKK activation
Kovalenko et al., Nature 2003 : CYLD has deubiquitinating activity that is directed towards non-K48 linked polyubiquitin chains, and negatively modulates TRAF mediated activation of IKK , strengthening the notion that ubiquitination is involved in IKK activation by TRAFs and suggesting that CYLD functions in this process
Sun et al., Mol Cell 2004 (Lymphoma, B-Cell, Marginal Zone) : RNAi mediated silencing of MALT1, TAK1, TRAF6 , and TRAF2 suppressed TCR dependent IKK activation and interleukin-2 production in T cells
Blackwell et al., Mol Cell Biol 2013 : Here, by assessing the kinetics and amplitude of I?B kinase ( IKK ) activation, we report that TNF-a induced immediate and robust activation of IKK requires K63 linked and linearly linked ubiquitination of RIP1 and that in the absence of RIP1 expression, TRAF2 and cIAP1 cooperatively induce delayed IKK activation by recruiting LUBAC to TNFR1