Matsumoto et al., J Neural Transm 2006
(Alzheimer Disease...) :
This paper presents that overexpression of wild-APP in the cells ( SH/w-APP ) increased the levels of APP and Abeta ( 1-40 ) but not Abeta ( 1-42 ), and reduced Bcl-2 level and proteasome activity with increased susceptibility to oxidative stress
Yang et al., Mech Ageing Dev 2009
(Neuroblastoma) :
We hypothesize that APP/HSP/Bcl-2 complexes diminish the functional capacities of HSPs and Bcl-2 , which leads to mitochondrial injury and apoptosis