Gene interactions and pathways from curated databases and text-mining

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ANGPT2 — IL8

Text-mined interactions from Literome

Skurk et al., Arterioscler Thromb Vasc Biol 2004 (Inflammation) : Ang II stimulates IL-6 and IL-8 production and release from human adipocytes by a NF-kappaB dependent pathway
Nabah et al., Circulation 2004 : In human umbilical vein endothelial cells ( HUVECs ) or human pulmonary artery media in culture, Ang II induced interleukin (IL)-8 mRNA expression at 1, 4, and 24 hours and the release of IL-8 at 4 hours through interaction with Ang II type 1 receptors
Estellés et al., J Leukoc Biol 2005 : BM also diminished Ang-II induced interleukin-8 release from endothelial cells and blocked the PAF receptor on human neutrophils ( concentration of the compound needed to produce 50 % inhibition value : 28.2 microM )
Inomata et al., Microbes Infect 2007 : In addition, angiopoietin (Ang)-2 , a substance of WPB, enhanced IL-8 production by P. gingivalis LPS, suggesting that Ang-2 mediates the RgpA induced enhanced cell responses
Zack et al., Atherosclerosis 2011 (Aortic Aneurysm, Abdominal...) : Ang II induction of cyclooxygenase-2, interleukin-6 , matrix metalloproteinase (MMP)-2, MMP-13 and MMP-14 was reduced significantly in GX DKO mice compared to apoE ( -/- ) mice
Neagoe et al., J Cell Physiol 2012 : Angiopoietin-1 but not angiopoietin-2 induces IL-8 synthesis and release by human neutrophils