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RELA — SMAD7
Text-mined interactions from Literome
Bitzer et al., Genes Dev 2000
:
Following stimulation with bacterial lipopolysaccharide (LPS), or the proinflammatory cytokines TNF-alpha and interleukin-1beta ( IL-1beta,
NF-kappaB/RelA induces
Smad7 synthesis through activation of Smad7 gene transcription ... These results suggest a mechanism of suppression of TGF-beta/SMAD signaling by opposing stimuli mediated through the
activation of inhibitory
Smad7 by
NF-kappaB/RelA
Lallemand et al., Oncogene 2001
:
Interestingly, the stable expression of oncogenic Ras in MDCK cells which suppressed
Smad7 inhibition of
NF-kappaB also suppressed Smad7 potentiation of serum withdrawal induced apoptosis and anoikis ... In addition,
Smad7 inhibited TNF-alpha stimulation of
NF-kappaB and increased TNF-alpha mediated apoptosis in MDCK cells
Kanamaru et al., J Biol Chem 2001
:
We also demonstrated that the induction of
Smad7 by NE is
dependent on
nuclear factor-kappa B (NF-kappa B)
Schiffer et al., J Clin Invest 2001
(Disease Models, Animal...) :
Unlike TGF-beta,
Smad7 inhibits nuclear translocation and transcriptional activity of the cell survival factor
NF-kappaB
Arsura et al., Oncogene 2003
(Carcinoma, Hepatocellular...) :
Transient activation of
NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1
inhibits AP-1/SMAD signaling and apoptosis : implications in liver tumor formation ... Furthermore, TGF-beta1 mediated upregulation of
Smad7 appeared
independent of
NF-kappaB
Monteleone et al., J Biol Chem 2004
(Crohn Disease) :
Indeed inhibiting
Smad7 by specific antisense oligonucleotides increased IkappaBalpha expression and
reduced NF-kappaB p65 accumulation in the nucleus
Tsunobuchi et al., Biochem Biophys Res Commun 2004
(MAP Kinase Signaling System) :
In addition, TPA up-regulated
Smad7 expression in the
presence of
NF-kappaB inhibitor TLCK
Ng et al., Kidney Int Suppl 2005
(Nephritis) :
Furthermore, gene transfer of
Smad7 also substantially
blocked nuclear factor kappa B (NFkappaB) activation in the rat remnant kidney ( P < 0.01 )
Wang et al., J Am Soc Nephrol 2005
(Disease Models, Animal...) :
Smad7 mediated inhibition of
NF-kappaB activation via the induction of IkBalpha may be the central mechanism by which latent TGF-beta prevents renal inflammation
Saika et al., Am J Pathol 2005
(Burns, Chemical...) :
Expression of exogenous Smad7 in burned corneal tissue resulted in reduced
activation of
Smad signaling and nuclear factor-kappaB signaling via
RelA/p65
Tzimas et al., Cell Signal 2006
:
Overexpression of USP31 in HEK 293T cells inhibited TNFalpha, CD40, LMP1, TRAF2, TRAF6 and IKKbeta mediated
NF-kappaB activation, but did not
inhibit Smad mediated transcription activation
Eliseev et al., Exp Cell Res 2006
(Bone Neoplasms...) :
Here, we show that in osteosarcoma Saos2 osteoblasts,
NFkappaB regulates the activity of the
BMP/Smad signaling ... We therefore conclude that in osteosarcoma Saos2 cells,
NFkappaB represses
BMP/Smad signaling and BMP2 induced differentiation through Smad7
Grau et al., Cell Signal 2006
(Colonic Neoplasms) :
Role of
Smad proteins in the regulation of
NF-kappaB by TGF-beta in colon cancer cells
Li et al., J Bone Miner Res 2007
(Osteoporosis) :
The
effect of TNFalpha induced
NF-kappaB signaling on
Smad signaling and on in vitro osteoblast mineralization was examined using specific NF-kappaB inhibitors and activators, and effects of TNFalpha induced NF-kappaB signaling on BMP-2 induced Runx2 mRNA were examined using RT-PCR
Baugé et al., Arthritis Rheum 2008
:
In addition, transient transfections of p65 expression vector or p65 targeted short hairpin RNA were performed to define the
effect of
NF-kappaB on
Smad7 expression
Graham et al., Prostate 2009
(Neoplasm Metastasis...) :
PI3K/Akt dependent transcriptional regulation and
activation of
BMP-2-Smad signaling by
NF-kappaB in metastatic prostate cancer cells ... In this study, we investigated whether the nuclear transcription factor
NF-kappaB , implicated in PC metastasis, is
involved in transcriptional regulation and activation of BMP-2 or
BMP-4/Smad signaling in PC cells ... Notably, the activation of BMPRII by BMP-2 is required for modulation of
Smad activation by
NF-kappaB in PC cells
Seo et al., Eur J Immunol 2009
:
Instead,
NF-kappaB overexpression
increased the expression of
Smad7 transcripts
An et al., American journal of physiology. Renal physiology 2009
(Fibrosis...) :
The untreated CRF rats exhibited proteinuria, hypertension, azotemia, upregulations of renal tissue NAD ( P ) H oxidase, MCP-1, COX-2, PAI-1, TGF-beta, Smad2, alpha-smooth muscle actin, fibronectin, and hepatocyte growth factor,
activation of ERK1/2 and
NF-kappaB , downregulation of
Smad7 , intense mononuclear leukocyte infiltration, tubulointerstitial fibrosis, and glomerulosclerosis
Freudlsperger et al., Oncogene 2013
(Carcinoma, Squamous Cell...) :
Furthermore, TGF-ß and
RELA activation
promoted SMAD7 expression