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NFKB1 — SOD1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Shi et al., Mol Cell Biochem 1999
:
This activation of
NF-kappaB was decreased by a metal chelator, diethylene triaminepentaacetic acid or a H2O2 scavenger, catalase, but was
increased by
superoxide dismutase
Wang et al., Ann Clin Lab Sci 1999
:
Superoxide dismutase ( SOD ) , but not catalase or sodium formate,
inhibited this
NF-kappaB activation, suggesting that O2*- rather than H2O2 or *OH, radicals play the most critical role in this induction
Darville et al., Endocrinology 2000
:
NF-kappaB is
required for cytokine induced manganese
superoxide dismutase expression in insulin producing cells
Ye et al., Ann Clin Lab Sci 2000
:
Exogenous
superoxide dismutase ( SOD ) enhanced the
NF-kappaB activation by PMA, while catalase blocked it
Jan et al., J Virol 2000
(Neuroblastoma) :
The finding that AACOCF ( 3 ) and
SOD significantly
block activation of
NF-kappaB suggests that this activation is derived from the AA-superoxide anion pathway
Kim et al., J Korean Med Sci 2000
(Acute Disease...) :
Present study aims to investigate whether neutrophils primed by 4beta-phorbol 12beta-myristate 13alpha-acetate ( PMA ) affect the productions of H2O2 and lipid peroxide (LPO),
NF-kappaB activation and cytokine production in pancreatic acinar cells, and whether these alterations were
inhibited by N-acetylcysteine (NAC) and
superoxide dismutase ( SOD )
Lehmann et al., Hepatology 2000
(Fatty Liver) :
SOD1 blunted this increase and
reduced the activation of
NF-kappaB
Huang et al., J Cereb Blood Flow Metab 2001
(Reperfusion Injury...) :
Immunohistochemistry showed
SOD1 overexpression
attenuated ischemia induced
NF-kappaB p65 immunoreactivity ... The current findings provide the first evidence that
SOD1 overexpression
attenuates activation of
NF-kappaB after transient FCI in mice and that preventing this early activation may block expression of downstream deleterious genes like c-myc, thereby reducing ischemic damage
Seo et al., Pharmacology 2002
:
Small-molecule antioxidants and
SOD inhibited
NF-kappaB activation and cytokine production in acinar cells caused by PMA primed neutrophils
Fan et al., J Biol Chem 2003
(Anoxia) :
Overexpression of glutathione peroxidase-1 or catalase, but not
Mn-SOD or Cu, Zn-SOD, significantly
reduced both
NF kappa B activation and tyrosine phosphorylation of I kappa B alpha
Casciati et al., J Neurochem 2002
(Amyotrophic Lateral Sclerosis...) :
In this paper, we report a calcineurin dependent activation of
nuclear factor-kappaB (NF-kappaB) induced by the expression of familial amyotrophic lateral sclerosis ( fALS )
-SOD1s in human neuroblastoma cell lines
Yang et al., Mol Ther 2003
(Myocardial Reperfusion Injury...) :
These findings support the notion that both mitochondrial and cytoplasmic derived
SOD induce changes in AP-1 and
NF kappa B activity, creating an antiapoptotic microenvironment within cardiomyocytes that affords protection following I/R injury
Cardoso et al., Free radical research 2003
(Alzheimer Disease) :
We observed that the
NF-kB inhibitor, PDTC,
prevented SOD overexpression after A beta treatment
Kaneko et al., Biol Pharm Bull 2004
:
Manganese
superoxide dismutase is
induced by endoplasmic reticulum stress through IRE1 mediated
nuclear factor (NF)-kappaB and AP-1 activation
Yune et al., J Neurotrauma 2004
(Spinal Cord Injuries) :
Manganese
superoxide dismutase induced by TNF-beta is
regulated transcriptionally by
NF-kappaB after spinal cord injury in rats
Song et al., J Cereb Blood Flow Metab 2005
(Brain Ischemia) :
However,
SOD 1
prevented NF-kappaB activation, and phosphorylation and degradation of IkappaBalpha after tFCI ... However,
SOD 1 prevented
NF-kappaB activation, and phosphorylation and degradation of IkappaBalpha after tFCI
Rui et al., FASEB J 2005
(Inflammation) :
NFkappaB and AP-1 differentially
contribute to the induction of
Mn-SOD and eNOS during the development of oxidant tolerance ... In this model, nuclear translocation of both
NF-kappaB and AP-1 is
required for induction of
Mn-SOD , while nuclear translocation of AP-1, but not NF-kappaB, is a prerequisite for induction of eNOS
Gomez-Cabrera et al., Br J Nutr 2006
:
In animal models, we previously showed that
NF-kappaB activation induced by exhaustive physical exercise
leads to an increase in the expression of
superoxide dismutase , an enzyme involved in antioxidant defence
Yang et al., Chin J Integr Med 2007
(Learning Disorders...) :
TCA could improve A beta 25-35 induced dysfunction of learning and memory in rats, and its protective mechanism is associated with its actions in decreasing MDA level, increasing
Mn-SOD activity and
inhibiting the expression of
NF-kappa B in cerebral cortex
Viña et al., Biol Chem 2008
:
Activation of
NF-kappa B by estrogens subsequently
activates the expression of
Mn-SOD and GPx, but genistein is only capable of activating Mn-SOD expression
Kiningham et al., Free Radic Biol Med 2008
(Neuroblastoma) :
All-trans-retinoic acid
induces manganese
superoxide dismutase in human neuroblastoma through
NF-kappaB
Xu et al., Planta Med 2008
(Infarction, Middle Cerebral Artery...) :
Pre-treatment with isosteviol reduced infarct volume, ameliorated cell death and infiltration of neutrocytes, improved neuro-locomotor activity, increased
SOD activity, induced Bcl-2,
suppressed lipid superoxidation and the expression of
NF-kappaB , and therefore retarded necrosis and apoptosis of neurons and inflammation
Zhang et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2008
(Disease Models, Animal) :
Compared with control group,
SOD activity in LPS group decreased at different time points significantly ( P < 0.05 or P < 0.01 ), but MPO activity, MDA content and the expression of
NF-kappaB increased obviously ( P < 0.05 or P < 0.01 ) ; the administration of MT and DEX could mitigate above values significantly ( P < 0.05 or P < 0.01 )
Lee et al., Exp Mol Med 2009
:
Tat-SOD inhibited LPS induced
NF-kappaB DNA binding activity, IkappaBalpha degradation and activation of MAP kinases
Shan et al., J Biomed Biotechnol 2009
(Brain Injuries...) :
Interestingly, we found, PSPC decreased the expression level of glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2),
inhibited nuclear translocation of nuclear factor-kappaB
(NF-kappaB) , increased the activity of copper/zinc
superoxide dismutase ( Cu/Zn-SOD ) and catalase (CAT), and reduced the content of malondialdehyde ( MDA ), respectively
Lee et al., Mol Cells 2010
(MAP Kinase Signaling System) :
Furthermore, cell-permeable
SOD inhibited LPS induced
NF-kappaB DNA binding activity and activation of MAP kinases including ERK, JNK, and p38 in BV-2 cells
Das et al., Mol Cell Biochem 1995
(Adenocarcinoma...) :
TNF alpha and IL-1 each can activate
NF-kappa B and
induce gene expression of manganese
superoxide dismutase ( MnSOD ), a mitochondrial matrix enzyme which can provide critical protection against hyperoxic lung injury
Weiss et al., J Immunol 1997
:
TNFR80 induces no cytotoxicity on its own, but is functional in these transfectants, as selective stimulation activates
nuclear factor-kappaB (NF-kappaB) and
induces NF-kappaB dependent cellular responses ( IL-6 and manganese
superoxide dismutase )
Marumo et al., Circulation 1997
:
In contrast,
superoxide dismutase did not
inhibit the interleukin-1beta induced
NF-kappaB activation
Schmidt et al., Chem Biol 1995
(Second Messenger Systems) :
In contrast, stable overexpression of cytoplasmic Cu/Zn dependent
superoxide dismutase ( SOD ) , which enhances the production of H2O2 from superoxide,
potentiated NF-kappa B activation
Borrello et al., Arch Biochem Biophys 1997
:
NF kappa B-independent transcriptional
induction of the human manganous
superoxide dismutase gene
Manna et al., J Biol Chem 1998
:
Besides TNF, phorbol ester-, okadaic acid-, ceramide-, and lipopolysaccharide induced activation of
NF-kappaB was
blocked by
Mn-SOD , indicating a common pathway of activation