◀ Back to NTRK1

NGFR — NTRK1

Pathways - manually collected, often from reviews:

• NCI Pathway Database p75(NTR)-mediated signaling: NGF (dimer)/TRKA complex (NTRK1-NGF) → NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs complex (NGF-NGFR-TRAF6-RIPK2-IRAK1-SQSTM1-PRKCI_PRKCZ) (modification, inhibits)
  Hamanoue et al., Mol Cell Neurosci 1999, Wooten et al., J Biol Chem 2001, Khursigara et al., J Neurosci 2001, Mamidipudi et al., J Biol Chem 2002, Yeiser et al., J Neurosci 2004, Carter et al., Science 1996
  Evidence: mutant phenotype, reporter gene, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: p75(NTR) (NGFR) → TRKA (NTRK1) (modification, activates) Watson et al., J Neurobiol 1999, Wiesmann et al., Nature 1999, Salehi et al., Neuron 2000, Qian et al., Mol Cell Biol 2001, Zaccaro et al., J Biol Chem 2001, Hartman et al., J Biol Chem 1992, Klein et al., Cell 1991, Kaplan et al., Science 1991, Hempstead et al., Nature 1991, Loeb et al., J Biol Chem 1994, Stephens et al., Neuron 1994, Benedetti et al., Proc Natl Acad Sci U S A 1993, Battleman et al., J Neurosci 1993, Cunningham et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: p75(NTR) (NGFR) → NGF (dimer)/TRKA complex (NTRK1-NGF) (modification, activates)
  Watson et al., J Neurobiol 1999, Wiesmann et al., Nature 1999, Salehi et al., Neuron 2000, Qian et al., Mol Cell Biol 2001, Zaccaro et al., J Biol Chem 2001, Hartman et al., J Biol Chem 1992, Klein et al., Cell 1991, Kaplan et al., Science 1991, Hempstead et al., Nature 1991, Loeb et al., J Biol Chem 1994, Stephens et al., Neuron 1994, Benedetti et al., Proc Natl Acad Sci U S A 1993, Battleman et al., J Neurosci 1993, Cunningham et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: p75(NTR) (NGFR) → NT3 (dimer)/TRKA complex (NTRK1-NTF3) (modification, inhibits)
  Huang et al., Development 1999*, Mischel et al., J Biol Chem 2001*, Clary et al., Proc Natl Acad Sci U S A 1994*, Benedetti et al., Proc Natl Acad Sci U S A 1993
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: p75(NTR) (NGFR) → TRKA (NTRK1) (modification, inhibits) Huang et al., Development 1999*, Mischel et al., J Biol Chem 2001*, Clary et al., Proc Natl Acad Sci U S A 1994*, Benedetti et al., Proc Natl Acad Sci U S A 1993
  Evidence: mutant phenotype, assay, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: NTRK1 — NGFR (physical association, fluorescence microscopy) Wolf et al., J Biol Chem 1995*
• IRef Dip Interaction: NTRK1 — NGFR (direct interaction, cross-linking study) Huber et al., J Neurosci Res 1995*
• IRef Dip Interaction: NTRK1 — NGFR (direct interaction, coimmunoprecipitation) Huber et al., J Neurosci Res 1995*
• IRef Hprd Interaction: NTRK1 — NGFR (in vivo) Bibel et al., EMBO J 1999*
• IRef Ophid Interaction: NTRK1 — NGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kahle et al., J Neurosci Res 1994 : It was found that NGF internalization was neither prevented by blocking p140trkA activity using the protein kinase inhibitors methylthioadenosine, staurosporine, and K-252a, nor by inhibiting NGF binding to p75NGFR with antibodies
Allsopp et al., J Cell Biol 1993 : The failure of trkA to result in an NGF promoted survival response in ciliary neurons is not due to absence of the low-affinity NGF receptor , p75, in these neurons