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CCND1 — SYT1

Text-mined interactions from Literome

Xie et al., Cancer Res 2002 (Sarcoma, Synovial...) : SYT-SSX is critical for cyclin D1 expression in synovial sarcoma cells : a gain of function of the t ( X ; 18 ) ( p11.2 ; q11.2 ) translocation ... Here we demonstrate that SYT-SSX is critical for the protein level of cyclin D1 in synovial sarcoma cells ... However, SYT-SSX regulated cyclin D1 expression was proven to be independent of the glycogen synthetase kinase-3beta pathway ... Taken together, our study provides evidence that SYT-SSX stabilizes cyclin D1 and is critical for cyclin D1 expression in synovial sarcoma cells ... SYT-SSX dependent expression of cyclin D1 may be an important mechanism in the development and progression of synovial sarcoma and also raises the possibility for targeted therapy
Wu et al., J Biol Chem 2011 : In rat growth plate chondrocytes, proepithelin induced NF-?B-p65 nuclear translocation, and nuclear NF-?B-p65 initiated its target gene cyclin D1 to regulate chondrocyte functions