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KRAS — RASA1

Pathways - manually collected, often from reviews:

• KEGG Axon guidance: RASA1 → HRAS/KRAS/NRAS (protein-protein, inhibition)
• KEGG MAPK signaling pathway: RASA1 → HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2 (protein-protein, inhibition)
  
• NCI Pathway Database IL2-mediated signaling events: RasGAP/Dok-R complex (RASA1-DOK2) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, inhibits)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: RasGAP/Dok-R complex (RASA1-DOK2) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, inhibits)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: SOCS3/RasGAP complex (SOCS3-RASA1) → RAS family/GDP/Aiolos complex (HRAS_KRAS_HRAS_KRAS_NRAS-IKZF3) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: SOCS3/RasGAP complex (SOCS3-RASA1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/RasGAP complex (SHC1-RASA1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Li et al., Science 1992, Stephens et al., Neuron 1994
  Evidence: assay, other species
• NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/RasGAP complex (SHC1-RASA1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Li et al., Science 1992, Stephens et al., Neuron 1994
  Evidence: assay, other species
• NCI Pathway Database Regulation of Ras family activation: KRAS isoform 4B/GTP complex (KRAS) → RasGAP (RASA1) (modification, collaborate) Alvarez-Moya et al., Oncogene 2010*
  Evidence: assay
• NCI Pathway Database Regulation of Ras family activation: RasGAP (RASA1) → KRAS isoform 4B/GDP complex (KRAS) (modification, activates)
  Alvarez-Moya et al., Oncogene 2010*
  Evidence: assay
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Elowe et al., Mol Cell Biol 2001
  Evidence: genetic interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Elowe et al., Mol Cell Biol 2001
  Evidence: genetic interaction
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
  Evidence: assay
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP complex (PDGFRB-RASA1-PDGFB) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Ekman et al., Oncogene 1999, Ekman et al., Oncogene 2002, Gibbs et al., J Biol Chem 1990, Bazenet et al., Oncogene 1994
  Evidence: assay
• Reactome Reaction: KRAS → RASA1 (reaction) Nava et al., FEBS Lett 2000*, Shu et al., Mol Cell Biol 2002, Wu et al., Oncogene 2003*
• Reactome Reaction: KRAS → RASA1 (indirect_complex)
• WikiPathways MAPK Signaling Pathway: RASA1 → MRAS/NRAS/KRAS (mim-inhibition)
• WikiPathways Rac1/Pak1/p38/MMP-2 pathway: RASA1 → HRAS/KRAS/NRAS (inhibition)

Text-mined interactions from Literome

Hendron et al., Mol Biol Cell 2002 (MAP Kinase Signaling System) : Renal A6 epithelial cells were used to determine whether induction of Ki-ras leads to concomitant increases in the total as well as active levels of Ki-RasA and whether this then leads to subsequent activation of its effector mitogen activated protein kinase ( MAPK/extracellular signal regulated kinase ) cascade
Wang et al., Int J Cancer 2003 (Colorectal Neoplasms) : We found that the extrinsic GTPase activity of the codon 15 mutant K-ras proteins ( p21 ( K-ras15M ) ) in the presence of GAP is much lower than that of the wild-type K-ras protein ( p21 BN ), whereas the intrinsic GTPase activity is nearly the same as that of the wild-type K-ras protein
Dasgupta et al., Cancer Res 2005 (Glioma...) : Collectively, our results show that K-RAS is the primary target for neurofibromin GTPase activating protein activity in vitro and in vivo and that K-RAS activation in astrocytes recapitulates the biochemical, biological, and tumorigenic properties of neurofibromin loss