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PPARA — STAT5B
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhou et al., J Biol Chem 1999
:
STAT5b inhibition was not reversed by overexpression of the heterodimerization partner of PPAR ( retinoid X receptor ) or the nuclear receptor coactivators P300 and SRC-1, suggesting that
STAT5b does not
inhibit PPARalpha by competing for these limiting cellular cofactors
Shipley et al., Mol Pharmacol 2003
:
PPAR did not
block STAT5b tyrosine phosphorylation or inhibit DNA binding activity ... Transcriptionally inactive, dominant negative
PPAR mutants did not
block STAT5b inhibition by wild-type PPAR, indicating that PPAR target gene transcription is not required
Zhou et al., J Biol Chem 1999
:
GH inhibition of
PPARalpha activity
required GH receptor and
STAT5b and was not observed using GH-activated STAT1 in place of STAT5b