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LPA — PPARA

Text-mined interactions from Literome

White et al., Front Biosci (Elite Ed) 2010 : A synergism model for PPARalpha and PXR agonist effects on HDL-cholesterol and apoA1
Stapleton et al., PloS one 2011 : The availability of Chinese Hamster Ovary ( CHO ) cells that stably overexpress GPAT1, allowed us to analyze PPAR? activation in the presence of LPA produced as an intracellular intermediate ... Extracellular LPA, phosphatidic acid ( PA ) or a membrane-permeable diacylglycerol had no effect, showing that PPAR? had been activated by LPA generated intracellularly ... These data suggest that LPA synthesized via the glycerol-3-phosphate pathway can activate PPAR? and that intermediates of de novo glycerolipid synthesis regulate gene expression
Tsukahara et al., Scientific reports 2012 (Colonic Neoplasms) : Accordingly, cPA-hydrogel microspheres substantially inhibited LPA induced PPAR? activity and cell growth and migration compared with that of cells cultured with cPA alone
Marchan et al., Cell cycle (Georgetown, Tex.) 2012 (Neoplasms) : LPA activates intracellular signaling pathways by binding to specific LPA receptors, including membrane bound G protein coupled receptors and the intracellular nuclear receptor, PPAR?
Tsukahara et al., Biochem Biophys Res Commun 2013 : We showed that alkyl-LPA ( 3µM ) significantly activated PPAR? and increased intracellular glucose levels in skeletal muscle cells