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HDAC1 — STAT3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: STAT3 — HDAC1 Yuan et al., Science 2005*
• IRef Bind_translation Interaction: STAT3 — HDAC1 (experimental interaction detection) Yuan et al., Science 2005*
• IRef Bind_translation Interaction: STAT3 — HDAC1 (coimmunoprecipitation) Yuan et al., Science 2005*
• IRef Biogrid Interaction: HDAC1 — STAT3 (physical association, affinity chromatography technology) Yang et al., FEBS Lett 2012*
• IRef Biogrid Interaction: HDAC1 — STAT3 (colocalization, imaging technique) Yang et al., FEBS Lett 2012*
• IRef Biogrid Interaction: HDAC1 — STAT3 (physical association, affinity chromatography technology) Zhang et al., Proc Natl Acad Sci U S A 2005*
• IRef Biogrid Interaction: HDAC1 — STAT3 (physical association, affinity chromatography technology) Yuan et al., Science 2005*
• IRef Biogrid Interaction: HDAC1 — STAT3 (physical association, affinity chromatography technology) Gupta et al., Leukemia 2012*
• IRef Hprd Interaction: STAT3 — HDAC1 (in vivo) Yuan et al., Science 2005*
• IRef Intact Interaction: STAT3 — HDAC1 (physical association, anti bait coimmunoprecipitation) Yang et al., FEBS Lett 2012*

Text-mined interactions from Literome

Ochrietor et al., Cytokine 2000 : Role of STAT3 and C/EBP in cytokine dependent expression of the mouse serum amyloid P-component (SAP) and C-reactive protein (CRP) genes
Ray et al., Nucleic Acids Res 2008 : Interestingly, over expression of HDAC1 in HepG2 cells leads to significantly reduced amounts of nuclear STAT3 after IL-6 induction, whereas silencing of HDAC1 resulted in accumulation of total and acetylated STAT3 in the nucleus
Sun et al., J Immunol 2009 : In this study we report that HDAC inhibition acetylates and activates STAT-3 , which regulates DCs by promoting the transcription of IDO
Pang et al., J Cell Biochem 2011 : Collectively, our results reveal an important role of HDAC1 and HDAC2 in regulating proliferation of renal interstitial fibroblasts, expression of cell cycle proteins and activation of STAT3