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LEP — RAC1
Text-mined interactions from Literome
Mattioli et al., FASEB J 2008
:
We found that in immature DCs,
leptin activates cofilin, favoring the turnover of actin microfilaments, and, by triggering Vav phosphorylation,
promotes Rac1 activation
Jaffe et al., Int J Cancer 2008
(Colonic Neoplasms...) :
A direct and novel dose- and time dependent
activation of RhoA, Cdc42 and
Rac1 by
leptin is demonstrated in these aggressive colon cancer cells ... The activation of the Rho family of GTPases was amenable to specific inhibition : Wortmannin inhibited
leptin induced
Rac1 and Cdc42 activation but did not affect RhoA activation, and inhibited the formation of leptin induced lamellipodia and cell invasion ... The Rac1 inhibitor NSC23766 inhibited only
leptin induced
Rac1 activation and concomitantly, lamellipodium formation and cell invasion ... The specific JAK2 inhibitor AG490 exerted a positive effect on
Rac1 and Cdc42
activation by
leptin and concomitantly inhibited RhoA activation
Jiang et al., Hepatology 2008
:
We found that
leptin induced the PI3K dependent activation of
Rac1 , and that nicotinamide adenine dinucleotide phosphate, reduced form ( NADPH ) oxidase activation was also implicated in this process
Zeidan et al., Mol Cell Biochem 2011
:
The specific mTOR inhibitor rapamycin ( 10 nM ) attenuated
leptin induced RhoA and
Rac1 activation
Shyu et al., Clin Sci (Lond) 2012
:
The inhibitory effect of atorvastatin on Ang II-induced
leptin expression was
mediated by
Rac , ROS and JNK pathways