◀ Back to LEP

LEP — MMP9

Text-mined interactions from Literome

Castellucci et al., Mol Hum Reprod 2000 : We demonstrate that leptin increases, in a dose dependent manner, the secretion of immunoreactive MMP-2 and fFN and enhances the activity of MMP-9 in cultured cytotrophoblastic cells
Park et al., Exp Mol Med 2001 (Arteriosclerosis...) : Leptin also induced increases of MMP-2, MMP-9 , TIMP-1, and Up-regulated the human coronary artery smooth muscle cells ( HCASMCs )
Quinton et al., Am J Reprod Immunol 2003 : Expression of leptin receptor isoforms in vitro : lack of effects of leptin on endometrial cytokine and MMP production ... The effect of leptin on cell growth and on the production of cytokines [Leukaemia Inhibitory Factor (LIF), interleukin 6 and tumour necrosis factor-alpha ] and matrix metalloproteinases ( MMP ) ( MMP2 and MMP-9 ) was also investigated ... Leptin had no effect on cytokine and MMP production by these cells
Schulz et al., Biol Reprod 2004 : Our results suggest that leptin may play a role in the establishment of the placenta during early pregnancy and that this function is dependent on MMP activity
Simopoulou et al., Osteoarthritis Cartilage 2007 (Obesity...) : Also, leptin had a detrimental effect on chondrocyte proliferation and induced IL-1beta production and MMP-9 and MMP-13 protein expression
Schram et al., J Mol Cell Cardiol 2008 : Here we investigated the effects of leptin , circulating levels of which are typically increased in obese individuals, on MMP and collagen expression and MMP activity in isolated cardiac myofibroblasts
Yeh et al., Glia 2009 (Brain Neoplasms...) : In addition, we found that the expression of matrix metalloproteinase-13 (MMP-13) but not of MMP-2 and MMP-9 was increased in response to leptin stimulation
Bao et al., Mol Biol Rep 2010 : Leptin significantly increased both gene and protein levels of MMP-2, MMP-9 , cathepsin D, and collagen II, while decreased bFGF markedly in cartilage
Tao et al., Arterioscler Thromb Vasc Biol 2013 (Aortic Aneurysm, Abdominal...) : Leptin and leptin receptor antigen were evident in all AAAs, and leptin, MMP-9 , and MMP-12 mRNA was increased relative to age matched nondilated controls