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LEP — NOTCH1
Text-mined interactions from Literome
Knight et al., Endocr Relat Cancer 2011
(Breast Neoplasms) :
Leptin induced transactivation of epidermal growth factor receptor (EGFR) is
involved in leptin mediated
Notch1 and survivin upregulation, demonstrating a novel upstream role of leptin-EGFR-Notch1 axis
Guo et al., PloS one 2011
(Mammary Neoplasms, Animal) :
Remarkably,
leptin up-regulated
Notch1-4/JAG1/Dll-4 , Notch target genes : Hey2 and survivin, together with IL-1 and VEGF/VEGFR-2 ... In addition, blockade of IL-1R tI inhibited
leptin induced
Notch , Hey2 and survivin as well as VEGF/VEGFR-2 expression ... These data suggest
leptin is an
inducer of
Notch ( expression/activation ) and IL-1 signaling modulates leptin effects on Notch and VEGF/VEGFR-2