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CDC42 — SPRR1A

Text-mined interactions from Literome

Böck et al., J Biol Chem 2000 : Cdc42 induced activation of the mixed-lineage kinase SPRK in vivo ... Unlike the PAK family of protein kinases, we find that the activation of SPRK by Cdc42 can not be recapitulated in an in vitro system using purified, recombinant proteins ... These studies suggest an additional component or cellular environment is required for SPRK activation by Cdc42
Vacratsis et al., J Biol Chem 2000 : We demonstrate that constitutively activated Cdc42 fully activates this monomeric SPRK mutant in terms of both autophosphorylation and histone phosphorylation activity and induces the same in vivo phosphorylation pattern as wild type SPRK ... These studies suggest that zipper mediated SPRK oligomerization is not required for SPRK activation by Cdc42 but instead is critical for proper interaction and phosphorylation of a downstream target, MKK4