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CCL4 — IL1B

Text-mined interactions from Literome

Zhang et al., Cell Immunol 2003 : Interleukin-1beta induces macrophage inflammatory protein-1beta expression in human hepatocytes ... We examined the role of interleukin-1beta (IL-1beta) , a multifunctional cytokine, in regulating the expression of macrophage inflammatory protein (MIP)-1beta in human hepatocytes ( Huh7 and HepG2 ) ... IL-1beta significantly enhanced MIP-1beta expression in these cells at both the mRNA and protein levels ... In addition, caffeic acid phenethyl ester ( CAPE ), a specific inhibitor of the activation of NF-kappaB, not only abolished IL-1beta mediated NF-kappaB promoter activation, but also blocked IL-1beta induced MIP-1beta expression ... These observations suggest that IL-1beta mediated up-regulation of MIP-1beta production in the hepatic cells may contribute a critical mechanism for continuous recruitment of inflammatory cell to liver and maintenance of inflammation
Sanchez et al., Osteoarthritis Cartilage 2004 (Osteoarthritis, Knee) : IL-1beta highly stimulated *NO, IL-8, IL-6, MIP-1beta and PGE ( 2 ) synthesis but decreased AGG and TGF-beta1 production
Sandell et al., Osteoarthritis Cartilage 2008 (Arthritis) : In the presence of IL-1beta , FGF-18 increased expression of ADAMTS-4, aggrecan, BMP-2, COL2A1, CCL3, CCL4 , CCL20, CXCL1, CXCL3, CXCL6, IL-1beta, IL-6, and IL-8 and decreased ADAMTS-5, MMP-13, CCL2, and CCL8
Tseng et al., Biochem Pharmacol 2008 : An elevated level of macrophage inflammatory protein-1beta ( MIP-1beta ) induced by IL-1beta has been correlated with chronic hepatic inflammatory disease ... However, molecular mechanism of IL-1beta induced MIP-1beta expression in hepatic cells is obscure ... Here, we demonstrated that HE-145 inhibited IL-1beta induced MIP-1beta expression in a dose dependent manner in Huh7 cells ... To understand the mode of action of HE-145, we first examined how IL-1beta induced MIP-1beta expression at the molecular level ... Using selective inhibitors, we found that JNK and p38 pathways participated in IL-1beta induced MIP-1beta expression ... The inhibitory effect of HE-145 on IL-1beta induced MIP-1beta promoter activity was completely reversed by overexpressing c-jun. Electrophoretic mobility shift assay ( EMSA ) and chromatin immunoprecipitation ( ChIP ) assay consistently revealed that HE-145 reduced c-jun binding to the AP-1/CRE site in vitro and in vivo ... Our results established a major role for c-jun in IL-1beta induced MIP-1beta expression in hepatic cells ... The reduction in IL-1beta induced c-jun expression and subsequent binding of the c-jun/CREB1 complex to AP-1/CRE site mainly contributed to the inhibitory action of HE-145 on IL-1beta induced MIP-1beta production
McManus et al., J Immunol 1998 : In response to LPS, TNF-alpha, or IL-1 beta , both MIP-1 alpha and MIP-1 beta were induced at the mRNA and protein levels in a dose- and time dependent manner