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CASP10 — TLR2

Text-mined interactions from Literome

Mariathasan et al., Nature 2004 (Inflammation...) : Unexpectedly, Ipaf-deficient macrophages activated caspase-1 in response to TLR plus ATP stimulation but not S. typhimurium
Ozören et al., J Immunol 2006 : ASC, but not TLR2 , is required for caspase-1 activation independent of NF-kappaB in Listeria infected macrophages
Miggin et al., Proc Natl Acad Sci U S A 2007 : However, we found that Mal was cleaved by caspase-1 and that inhibition of caspase-1 activity blocked TLR2- and TLR4 mediated NF-kappaB and p38 MAP kinase activation but not IL-1 or TLR7 signaling, which are Mal independent
Lehnardt et al., J Immunol 2007 : Instead, interaction of GBS with TLR2 results in formation and activation of caspase-8 , a process that involves the transcription factor family Ets
Hewinson et al., J Immunol 2008 (Ion Channel Gating) : P2X(7) receptors ( P2X(7)Rs ) are ATP gated ion channels that trigger caspase-1 activation in the presence of TLR ligands
Netea et al., Blood 2009 (Inflammation) : Controversy has arisen whether Toll-like receptor ( TLR ) ligands alone can activate caspase-1 for release of interleukin-1beta (IL-1beta)
Hurst et al., Immunobiology 2009 (Antiphospholipid Syndrome) : Determination of expression-levels using real-time RT-PCR showed significantly augmented TLR dependent IL-1beta and caspase-1 expression
Harder et al., J Immunol 2009 (Disease Models, Animal...) : Notably, activation of caspase-1 by TLR2 and TLR4 ligands in the presence of streptolysin O required Myd88/Trif, whereas that induced by S. pyogenes was blocked by inhibition of NF-kappaB