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RPGR — WNT16
Text-mined interactions from Literome
Dann et al., Nature 2001
:
Recently, an LDL-receptor related protein has been shown to function as a co-receptor for Wnt proteins and to bind to a Frizzled
CRD in a
Wnt dependent manner
Kameya et al., Hum Mol Genet 2002
(Disease Models, Animal...) :
The
CRD is
essential for
Wnt binding and signaling
Noubissi et al., Cancer Res 2009
(Colorectal Neoplasms) :
Wnt/beta-catenin signaling
induces expression of an RNA binding protein,
CRD-BP , which in turn binds and stabilizes GLI1 mRNA, causing an elevation of GLI1 expression and transcriptional activity
Bhat et al., J Cell Biochem 2010
:
The Fz
CRD is also
critical for
Wnt signaling, as a deletion of 29 amino acids in the 2nd cysteine loop resulted in the total loss of TCF-luciferase activation