Fu et al., Acta Biochim Biophys Sin (Shanghai) 2006
(Carcinoma, Hepatocellular...) :
Our results showed that integrin beta ( 1A ) increased the p27 protein amount, both in cytoplasm and nucleus, but did not affect the p27 mRNA amount
Fu et al., J Cell Biochem 2007
(Carcinoma, Hepatocellular...) :
PI3K inhibitor LY294002 upregulated p27 ( Kip1 ) at post-translational level and downregulate Skp2 at mRNA level, which could mimic the effects of integrin beta1 overexpression on p27 ( Kip1 ) and Skp2