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EPHB2 — IL6

Text-mined interactions from Literome

Valledor et al., J Biol Chem 2000 : Granulocyte/macrophage colony stimulating factor, interleukin 3, and TPA, all of which induced macrophage proliferation, also induced ERK activity, which was maximal at 5 min poststimulation
Tancredi et al., J Neurochem 2000 (Synaptic Transmission) : Both effects of IL-6 on STAT3 and MAPK/ERK activation were effectively counteracted by LavA treatment
Lee et al., J Immunol 2000 (MAP Kinase Signaling System) : Studies using pharmacological inhibitors demonstrate that both p38 MAPK and ERK1/2 are involved in ICAM-1 induced IL-6 expression, whereas only ERK1/2 is important for IL-1alpha and IL-1beta expression
Harcourt et al., Eur J Biochem 2001 (MAP Kinase Signaling System) : Pharmacologic inhibition of either the ERK or the p38 MAPK pathway, using U0126 and SB203580, respectively, reduced interleukin-6 protein induction by at least 70 %, and combined inhibition of both pathways fully blocked interleukin-6 protein expression and reduced interleukin-6 mRNA induction by more than 80 %
Kuo et al., Oncogene 2001 : In Hep3B cells, the JAK/STAT3, ERK , and PI 3-K/Akt pathways were activated by IL-6 stimulation
Abe et al., Osaka City Med J 2001 : Interestingly, no requirement of the Y759 mediated signals, including SHP-2 mediated Erk/MAP kinase pathway, coincided with the failure of SHP-2, Gab1/Gab2, and Erk/MAP kinase activation by IL-6 in MH60 cells
Tokunou et al., Arterioscler Thromb Vasc Biol 2001 : These results suggest that the CRE site and CREB play an important role in thrombin induced IL-6 gene expression in VSMCs. Transactivation of EGF-R and activation of ERK and p38 MAPK are involved in this process
Ishikawa et al., Blood 2002 (Multiple Myeloma) : In multiple myeloma, IL-6 only enhanced the proliferation of CD45+ tumor cells that harbored the IL-6 independent activation of src family kinases even though STAT3 and ERK1/2 could be activated in response to IL-6 in both CD45+ and CD45 ( minus sign ) cells
Le Gouill et al., Leukemia 2002 (Multiple Myeloma) : The phosphorylation of both STAT3 and ERK1/2 induced by IL-6 was totally blocked at 15 microM of R115777 and partially blocked when R115777 was used at 10 and 5 microM
Legendre et al., J Biol Chem 2003 : JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes
Kawano et al., Int J Hematol 2002 (MAP Kinase Signaling System...) : In both CD45- and CD45+ U-266 cells, STAT3 and MAPK(ERK1/2) can be activated in response to IL-6 equally between them, but src family kinases such as Lyn, Fyn can be activated only in CD45+ U-266 cells
Sengul et al., American journal of physiology. Renal physiology 2003 : Inhibitors of ERK , JNK, and p38 reduced LC-induced IL-6 and MCP-1 production
Maggi et al., J Biol Chem 2003 (Cardiovirus Infections...) : ERK activation is required for double stranded RNA- and virus induced interleukin-1 expression by macrophages
MacGillivray et al., J Biol Chem 2003 (MAP Kinase Signaling System) : The protein tyrosine phosphatase SHP-2 regulates interleukin-1 induced ERK activation in fibroblasts
Shi et al., Mol Cancer Ther 2003 (Multiple Myeloma) : FTIs were also able to abrogate the IL-6 proliferative response of WT ras expressing MM cells, and this was associated with inhibition of IL-6 induced activation of ERK , AKT, and p70
Xie et al., J Immunol 2003 : Furthermore, LPS up-regulated the secretion of IL-1beta, IL-6 , IL-8, IL-10, and TNF-alpha ; reduced Ag presentation capacity ; and inhibited phosphorylation of ERK , but activated p38, leading to a reduced NF-kappaB activity in treated cells
Ruiz et al., J Biol Chem 2004 : 15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram negative bacteria induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity
Chang et al., J Biol Chem 2004 (Inflammation...) : The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation ... The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation
Wang et al., J Biol Chem 2005 : SHP-2 modulates interleukin-1 induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
Moran et al., Liver Int 2005 (Carcinoma, Hepatocellular...) : Using in vitro cell cultures, we demonstrated that IL-6 stimulated STAT3 and extracellular regulated kinase (ERK) activity in both HCC cells and isolated hepatocytes ... However, while STAT3 activation profiles were similar, IL-6 stimulated ERK activity in a biphasic manner in HCC cells and a monophasic, sustained ERK activation in hepatocytes
Li et al., J Biol Chem 2005 (Arteriosclerosis...) : However, MKK3/p38 signaling was specifically involved in TNF-alpha induction, and Erk1/2 signaling was required for IL-6
Deura et al., Fertil Steril 2005 (Endometriosis...) : IL-6 markedly enhanced the phosphorylation of ERK1/2 , but not Stat3 and p38 MAPK ... U0126 markedly reduced the level of the IL-6 induced phosphorylation of ERK1/2
Jeong et al., Hear Res 2005 (MAP Kinase Signaling System) : Increased IL-6 by DFX was significantly inhibited by p38 inhibitor, SB203580 ( about 72 % inhibition, P=0.027 ) but not ERK inhibitor, PD98059 or JNK inhibitor, SP600125
Legendre et al., J Rheumatol 2005 (MAP Kinase Signaling System) : IL-6/sIL-6R markedly induced activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3, an aggrecan degrading enzyme and activator of pro-MMP
Wang et al., Cell Signal 2005 (MAP Kinase Signaling System...) : Differential activation of the MEK/ERK and PI3K/AKT pathways that result in differential secretion IL-6, IL-8, TIMP-2 and VEGF were seen contingent on the cell type examined ; VEGF and TIMP-2 expression in PC3 cells are dependent on AKT activation and ERK activation in LNCaP and LNCaP C4-2B cells leads to IL-6 or IL-8 secretion
Miranda et al., Leuk Res 2005 (MAP Kinase Signaling System) : Additionally, interleukin-3 , which inhibits G-CSF induced differentiation of 32 Dc l3 cells, also inhibited the ability of G-CSF to stimulate prolonged MEK/ERK activation
Ganesan et al., Blood 2006 (Inflammation) : Inhibition of Ras/Erk or PI3K suppressed the enhanced production of IL-6 in SHIP-deficient macrophages
Thobe et al., Am J Physiol Cell Physiol 2006 (Anoxia...) : Furthermore, administration of PP1 prevented the hypoxia induced increase in IL-6 but not MCP-1 release by KC. Additional in vitro results suggest that p38 but not ERK1/2 or JNK are critical for KC IL-6 production
Aoki et al., J Cell Biochem 2006 : In addition, IL-6 activated ERK in PSCs
Hayer et al., Arthritis Rheum 2007 (Arthritis...) : Early lesions were associated with up-regulation of interleukin-1 (IL-1) and IL-6 as well as activation of p38 MAPK and ERK
Kwon et al., J Dermatol Sci 2007 (MAP Kinase Signaling System) : These results suggest that SPC induced IL-6 production is mediated by PKC dependent p42/44 ERK activation in human dermal fibroblasts cultured in vitro
Gazi et al., Clin Chim Acta 2007 (Prostatic Neoplasms) : Interestingly, although sodium selenite did not show effect on activation of both STAT3 and ERK1/2 in the presence of IL-6 , an increased expression of c-Jun was detected in cells after treatment with sodium selenite
Kobayashi et al., Eur J Pharmacol 2007 : These results suggest that ERK and calcineurin are cooperatively involved in UTP induced IL-6 production
Sanz et al., Glia 2008 : The binding of IL-6 to its receptor (IL6R) triggers gp130 mediated activation of STAT1 and STAT3 as well as SHP2 phosphatase and ERK1/2
Yang et al., Cell Signal 2008 (MAP Kinase Signaling System) : IL-1beta stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6 , IL-8 and GRO-alpha in HeLa cells
Krady et al., J Neurosci Res 2008 : IL-6 markedly increases STAT-3 and ERK phosphorylation after 20 min of treatment, whereas these signal transducers are weakly stimulated by CNTF across a range of doses
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Sobota et al., Cell Signal 2008 : Mouse embryonic fibroblasts expressing a SIRP1alpha protein which lacks the intracellular part show enhanced SHP2 phosphorylation and ERK1/2 activation in response to IL-6 , suggesting that SIRP1alpha affects IL-6 signalling through SHP2
Kang et al., Cell Prolif 2008 (MAP Kinase Signaling System) : Interestingly, IL-6 activated MAPKs but EGF did not influence JAK2/STAT3 activation ; AG490 specifically inhibited IL-6 induced Erk1/2 phosphorylation without affecting IL-6 induced phosphorylation of Raf and MEK1/2
Kogut et al., Innate Immun 2008 : Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2 dependent activation of AP-1 and NF-kappaB signaling pathways
Hashizume et al., Rheumatology (Oxford) 2008 (Arthritis, Rheumatoid) : Finally, IL-6/sIL-6R induced phosphorylation of STAT3 and ERK1/2 in RA-FLS, and was completely inhibited by PAR and PD, respectively
Sommer et al., Vet Immunol Immunopathol 2009 : In uninfected cells, inhibition of MAPK revealed that CD40L mediated increase in IL-6 gene expression was dependent on activation of ERK1/2 , while increases in IL-12p40, iNOS, and IL-10 gene expression were dependent on activation of p38
Wang et al., Neurosci Lett 2009 : IL-6 induced STAT3 phosphorylation was inhibited by AG490 but not by PD98059 ; and IL-6 induced ERK1/2 activation was blocked by PD98059 but not by AG490
Kirchmeyer et al., Arthritis Res Ther 2008 (MAP Kinase Signaling System) : Among RAR and RXR agonists, only ATRA inhibited IL-1 induced IL-6 expression in rat synovial fibroblasts by inhibiting ERK1/2 pathway and subsequent activation of AP-1 and NF-IL-6 independently of RAR
Huang et al., J Mol Endocrinol 2009 : Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation ... Finally, the CRH-R antagonists alpha-helical ( 9-41 ) CRH and astressin-2B completely inhibit Ucn induced IL-6 release, as well as activation of ERK , p38, and NF-kappaB
Chan et al., J Pharmacol Exp Ther 2009 (Pancreatitis) : cAMP-responsive element binding protein ( CREB ) might be involved in ERK1/2 induced IL-6 expression because phosphorylation of CREB was observed after angiotensin II treatment, which was reversed by losartan and the ERK1/2 inhibitor
Lin et al., Journal of neuroinflammation 2009 : Whereas IL-6 activated STAT-3 and ERK phosphorylation, CNTF did not activate these pathways, nor did CNTF increase p38 MAP kinase phosphorylation
Wang et al., FASEB J 2009 (MAP Kinase Signaling System) : In the present study, we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the ERK dependent up-regulation of IL-1beta, TNF-alpha, and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord
Park et al., Mol Oncol 2008 (Multiple Myeloma) : Upon treatment with curcumin, IL-6/sIL-6R induced STAT3 and Erk phosphorylation was dramatically reduced in the co-cultured cells ... In a combination treatment with curcumin and bortezomib, IL-6/sIL-6R induced STAT3 and Erk phosphorylation was effectively inhibited
Filer et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid) : The MAPKs p38, JNK, and ERK were necessary for IL-6 production, but phosphatidylinositol 3-kinase ( PI 3-kinase ) was required for selective CCL5 induction
Woolson et al., Cell Signal 2009 : Here we demonstrate that elevation of cyclic AMP ( cAMP ) levels in human umbilical vein endothelial cells ( HUVECs ) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-alpha/IL-6 ( sIL-6R alpha/IL-6 ) trans signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate ... The inhibitory effects of cAMP on sIL-6R alpha/IL-6 stimulated phosphorylation of ERK1,2 and STAT3 were abolished by either short interfering ( si ) RNA mediated knockdown or genetic ablation of suppressor of cytokine signalling-3 ( SOCS-3 ) ... Interestingly, the ability of cAMP elevation to inhibit IL-6 signalling was blocked by ERK inhibition
Saraiva et al., Immunity 2009 : Interleukin-10 production by Th1 cells requires interleukin-12 induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6 , and IL-12 p40, and the activation of ERK1/2 and p38 ... Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6 , and IL-12 p40, and the activation of ERK1/2 and p38
Totlandsdal et al., Toxicol In Vitro 2010 : Cellular release of IL-1alpha, IL-1beta and IL-6 was significantly attenuated by curcumin and by inhibitors of the MAPKs ERK1/2 ( PD98069 ), p38 ( SB202190 ) and JNK ( SP600125 ), whereas pyrrolidine dithiocarbamate ( PDTC ) attenuated the release of IL-6, but not of IL-1alpha and IL-1beta
Iqbal et al., Biochem Biophys Res Commun 2010 (Multiple Myeloma) : The IL-6 induced phosphorylation of STAT3 and ERK1/2 was not up-regulated in the Lyn overexpressed cells, indicating that the Lyn-PI 3-kinase-Akt pathway is independent of these pathways
Nomi et al., Invest Ophthalmol Vis Sci 2010 : The zymosan induced release of IL-6 and IL-8 was attenuated by inhibitors of ERK , p38, JNK, and NF-kappaB signaling
Zha et al., PloS one 2010 : Berberine significantly inhibited HIV PI-induced TNF-alpha and IL-6 expression by modulating ER stress signaling pathways and subsequent ERK activation, in turn preventing the accumulation of the RNA binding protein HuR in cytosol and inhibiting the binding of HuR to the 3'-UTRs of TNF-alpha and IL-6 in macrophages
Huang et al., Mediators Inflamm 2009 (MAP Kinase Signaling System) : Upregulation of Salmonella induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor : involvement of PI3K, p38 MAPK, ERK , JNK, and NF-kappaB
Xuan et al., Cell Physiol Biochem 2010 : Both LPS and GA stimulated the production of IL-6 , IL-10, IL12p70 and TNFalpha in a p38- and/or ERK dependent manner
Chen et al., Biochem Biophys Res Commun 2010 (Bone Resorption...) : ERK1/2 is involved in cyclic compressive force induced IL-6 secretion in MLO-Y4 cells
Fan et al., J Cell Physiol 2011 : Inhibitors of AMPK ( araA ), p38MAPK ( SB202190 ), and ERK1/2 ( PD98059 and U0126 ) but not JNK ( SP600125 ) suppressed gAd induced IL-6 production
Lo et al., Cancer Res 2011 (Ascites...) : ERK activation by the IL-6/sIL-6Ra complex increased endothelial integrity via Src kinase activation and Y685 phosphorylation of VE-cadherin
Wang et al., Inflamm Res 2011 : TNF-a induced phosphorylation of ERK1/2 and JNK, and TNF-a induced IL-6 expression and release were inhibited by selective ERK1/2 and JNK blockers
Vitiello et al., Microbiol Immunol 2011 : Using two potent and selective inhibitors of MEK activation by Raf-1 ( PD-098059 ) and p38 ( SB-203580 ), it was also demonstrated that both ERK1/2 and p38 pathways play key roles in the production of IL-6 as well as in ICAM-1, VCAM-1 and E-selectin expression by Hib porin
Kim et al., Immune network 2011 : We further demonstrated that JNK activation was required for TAT-CD137Lct induced production of TNF-a, while activation of Erk and p38 MAPK were involved in IL-6 and TNF-a production
Luckett-Chastain et al., J Interferon Cytokine Res 2012 : Inhibition of STAT3 in fibroblasts potentiated IL-6R induced ERK phosphorylation and vice versa
Chao et al., Connect Tissue Res 2012 (Hypertrophy...) : It was also found that NF-?B inhibitor, but not ERK1/2 inhibitor, attenuated EDP dependent induction of IL-1a, IL-1ß, and IL-6 expression, indicating that NF-?B pathways are required for EDP induced IL-1a, IL-1ß, and IL-6 gene expression in human LF cells
Chen et al., J Mol Med (Berl) 2012 (Multiple Myeloma) : Further analysis demonstrated that ISL not only downregulated IL-6 expression but also significantly decreased levels of phosphorylated ERK and STAT3 and could inhibit phosphorylation levels of ERK and STAT3 induced by recombinant human IL-6 , which are critical signaling proteins in IL-6 signaling regulation networks
Maza et al., Microbes Infect 2012 : Moreover, P. brasiliensis yeasts induced activation of p38 mitogen activated protein kinase ( MAPK ), c-Jun NH ( 2 ) -terminal kinase ( JNK ) and extracellular signal regulated kinase ( ERK ) 1/2 in A549 cells, and IL-8 and IL-6 secretion promoted by this fungus was dependent on activation of p38 MAPK and ERK 1/2
Kim et al., Parasite Immunol 2013 : N. fowleri mediated IL-1ß and IL-6 expression requires ERK , JNK and p38 mitogen activated protein kinases ( MAPKs ) activation in astrocytes
Nasimian et al., Inflamm Res 2013 : NF-kB, JNK, p38 and ERK specific inhibitors significantly reduced the production of TNF-a and IL-6 in macrophages stimulated with palmitate and also PTP1B knockdown cells
Fahmi et al., Cell Signal 2013 (Hypertrophy...) : In conclusion, IL-6 can signal in cardiomyocytes independent of sIL-6R and STAT1/3 and furthermore, that Erk1/2 and PI3K activation by IL-6 are both necessary and sufficient for induced cardioprotection
Wang et al., Mol Cell Biochem 2013 : By western blot analysis, DHA and EPA inhibited IL-6 induced STAT3 phosphorylation but not ERK1/2 or C/EBPß
Geletu et al., Biochim Biophys Acta 2013 (MAP Kinase Signaling System) : Further examination indicated that, although IL6 was able to activate Erk in sparsely growing cells, IL6 could not induce an increase in Erk activity levels in densely growing cultures ... Most importantly, cadherin-11 knock-down did allow Erk activation by IL6 at high densities, indicating that it is indeed cadherin engagement that prevents Erk activation by IL6
Lee et al., Food Chem Toxicol 2013 : Further studies revealed that PL suppressed the production of tumor necrosis factor-a (TNF-a) or Interleukin (IL)-6 and activation of nuclear factor-?B ( NF-?B ) or extracellular regulated kinases (ERK) 1/2 by LPS
Li et al., Mol Cell Biochem 2013 (MAP Kinase Signaling System) : IL-6 also induces a temporary and significant activation of ERK , but not sustained activation, and change sustained activation in MPP ( + ) -treated group into temporary activation
Wei et al., Spine (Phila Pa 1976) 2013 : IL-1 induced nitric oxide, prostaglandin E-2, and IL-6 accumulation were also reduced by ERK inhibition
Tsai et al., PloS one 2013 : Bla g 2 can stimulate up-regulation of inflammatory cytokines including TNF-alpha and IL-6 and activation of nuclear factor kappa B ( NF-kB/p65 ), p38 mitogen activated protein kinase ( p38 ), ERK , and JNK in cultured fibrocytes ... This increased secretion of TNF-alpha and IL-6 and activation of NF-kB, ERK , and JNK was significantly inhibited by the addition of either mannan or mannose
Wu et al., J Biol Chem 1996 : Mechanistically, NGF and bFGF induce a sustained phosphorylation and activation of ERK1 and ERK2 in both cells, while IL-6 produces only a transient and weak tyrosine phosphorylation
Wu et al., J Biol Chem 1996 : Importantly, IL-6 does not enhance ERK phosphorylation in the presence of either NGF or EGF
Geng et al., J Clin Invest 1996 : However, ERK was also activated by PDGF, IGF-1, and IL-6
Berger et al., Blood 1997 (Multiple Myeloma) : Prior treatment of U266 cells with IFN-beta downregulated IL-6 induced tyrosine phosphorylation of gp130, Jak2, PTP1D/Syp, Shc, and Erk2 , and GTP loading of p21ras
Lo et al., J Biol Chem 1998 : Requirements of focal adhesions and calcium fluxes for interleukin-1 induced ERK kinase activation and c-fos expression in fibroblasts