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GRAP2 — MMP9
Text-mined interactions from Literome
Ringshausen et al., Leukemia 2004
(Leukemia, Lymphocytic, Chronic, B-Cell) :
We showed that the constitutive expression of
MMP-9 was
dependent on
p38-activity and inhibition of p38 strongly downregulated MMP-9 expression
Kim et al., Invest Ophthalmol Vis Sci 2005
:
To evaluate the effects of TGF-beta1 and doxycycline on production of gelatinase
MMP-9 and
activation of Smad, c-Jun N-terminal kinase (JNK), extracellular regulated kinase (ERK), and
p38 mitogen activated protein kinase ( MAPK ) signaling pathways in human corneal epithelial cells
Cheung et al., Cancer Res 2006
(Neoplasm Invasiveness...) :
In addition, we showed that the c-Jun NH ( 2 ) -terminal kinase, but not extracellular signal regulated kinase 1/2 or
p38 mitogen activated protein kinase, signaling pathway was
critical for GnRH mediated up-regulation of
MMP , cell invasion, and motility
Sanka et al., Invest Ophthalmol Vis Sci 2007
:
Primary human TM ( HTM ) cells treated with different actin cytoskeleton interfering agents, including cytochalasin D, latrunculin A, ethacrynic acid ( ECA ), a Rho kinase inhibitor ( Y-27632 ), and H-7 ( serine/threonine kinase inhibitor ), were examined for changes in actin cytoskeletal organization by phalloidin staining,
MMP-2 activation by gelatin zymography, expression of MT1-MMP by quantitative real-time PCR analysis, levels of tissue inhibitor of metalloproteinases ( TIMP-1 and TIMP-2 ), and
activation of
p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular signal regulated protein kinase ( ERK ) by immunoblotting
Xue et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid...) :
Furthermore, APC directly suppressed the production of tumor necrosis factor (TNF) and the activation of NF-kappaB and MAP kinase p38, and inhibitors of NF-kappaB or
p38 reduced the production of
MMP-9 , suggesting that APC inhibits MMP-9 by blocking TNF, NF-kappaB, and p38
Turner et al., Matrix Biol 2010
:
Pharmacological inhibitors of
p38-a/ß ( SB203580 ) or p38-a/ß/?/d ( BIRB-0796 ) reduced MMP-3 and ADAMTS1 mRNA expression, but neither inhibitor
affected MMP-9 levels
Dumitru et al., J Leukoc Biol 2012
(Head and Neck Neoplasms...) :
Most importantly, HNC induced
p38-MAPK activation strongly
stimulates the release of CCL4, CXCL8, and
MMP9 by neutrophils
Hsu et al., J Cell Physiol 2012
(Colonic Neoplasms) :
After administration of inhibitors including QNZ ( NF?B inhibitor ), LY294002 ( Akt activation inhibitor ), U0126 ( ERK1/2 inhibitor ), SB203580 ( p38 MAPK inhibitor ) or SP600125 ( JNK1/2 inhibitor ), E ( 2 ) -downregulated cell migration and expression of MMP-2 and
MMP-9 in LoVo cells is markedly
inhibited only by
p38 MAPK inhibitors, SB203580
Tang et al., Nan Fang Yi Ke Da Xue Xue Bao 2012
(Brain Edema...) :
Blocking p38 signal pathway can attenuate MMP-9 upregulation and brain edema after TBI, suggesting the important
role of
p38 in regulating
MMP-9 expression to affect traumatic brain edema
Yen et al., TheScientificWorldJournal 2013
(Gingival Neoplasms...) :
After CTXIII treatment, the MMP-2 and
MMP-9 protein expressions were downregulated, and the phosphorylation of JNK and
p38-MAPK was
increased independent of ERK phosphorylation