Zhang et al., Am J Physiol Cell Physiol 2006
:
Pertussis toxin ( PTX ) blocks LPA induced activation of p38 and ERK but only slightly inhibits LPA induced activation of Akt
Kalari et al., Am J Physiol Lung Cell Mol Physiol 2009
(MAP Kinase Signaling System) :
Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold ) and attenuated LPA induced p38 MAPK, JNK, and NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion