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EPHB2 — SPRY1

Text-mined interactions from Literome

Ishida et al., Cancer Sci 2007 (Neuroblastoma) : Expression of SPRY1, SPRY2, SPRY3 and SPRY4 in HEK293T cells transfected with RET and GDNF receptor family alpha1 ( GFRalpha1 ) genes significantly reduced sustained ERK activation as well as ELK-1 activation
Yang et al., Dev Biol 2008 : Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia ... In addition, overexpression of Spry1 resulted in sustained ERK activation and increased expression of p21 and STAT1
Burgess et al., BMC developmental biology 2010 : Phospho-Erk1 and Erk2 levels were elevated in the lens but not in the cornea and Spry 1 and Spry 2, negative regulators of Ras-Raf-Erk signaling, were upregulated more in the corneal than in the lens epithelial cells
Charles et al., Mol Cell Biochem 2010 (Ventricular Remodeling) : The goal of this study was to test the hypothesis that up-regulated expression of Spry1 in cardiac myocytes would be sufficient to inhibit ERK1/2 activation and tissue remodeling
Jung et al., Stem Cells Dev 2012 (MAP Kinase Signaling System) : However, suppression of Spry1 expression and subsequent activation of ERK1/2 signaling promoted neural differentiation and inhibited endothelial differentiation of mESCs