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EPHB2 — SOS2

Text-mined interactions from Literome

Takeuchi et al., Am J Physiol 1999 : To examine the functional role of Sos in ERK2 activation, we transfected parietal cells with the HA-ERK2 vector together with a dominantly expressed mutant ( inactive ) sos gene ... Dominant negative Sos did not affect carbachol stimulation of HA-ERK2 but inhibited the stimulatory effect of EGF by 60 %
Sajan et al., J Biol Chem 1999 : In addition to requirements for PI3K, PDK-1, and PKC-zeta, we found that a tyrosine kinase ( presumably the insulin receptor ), the SH2 domain of GRB2, SOS , RAS, RAF, and MEK1 were required for insulin effects on ERK in the rat adipocyte
Kimura et al., Cancer Res 1999 (Ovarian Neoplasms) : Activation of ERK by GnRHa occurred within 5 min, with the maximum occurring at 3 h and sustained until 24 h. GnRHa also activated ERK kinase ( mitogen activated protein/ERK kinase ) and resulted in an increase in phosphorylation of son of sevenless ( Sos ) , and Shc
Caverzasio et al., J Bone Miner Res 2000 : In contrast to their implication in epidermal growth factor (EGF) receptor tyrosine kinase signaling, the adaptor protein Shc, the Grb2/Sos complex, and the small G protein Ras were not involved in the activation of Erk induced by either LPA or PGF2alpha in MC3T3-E1 cells, suggesting that activation of Erk by Gi and Gq protein coupled receptors is Ras independent in these cells
Nakamura et al., Oncogene 2002 (MAP Kinase Signaling System) : Here we determined the efficacy of Shc and N-Shc toward Erk activation in NGF treated PC12 cells, and found that N-Shc transduced Grb2/Sos/Ras dependent Erk activation less efficiently than Shc
Correa-Meyer et al., Am J Physiol Lung Cell Mol Physiol 2002 (MAP Kinase Signaling System) : The inhibition of Grb2-SOS interaction with an SH3 binding sequence peptide, Ras with a farnesyl transferase inhibitor, and Raf-1 with forskolin did not affect the stretch induced ERK1/2 phosphorylation
Yamasaki et al., Oncogene 2003 (Cell Transformation, Neoplastic) : EGF dependent GTP/GDP exchange activity for Ras was suppressed in the Gab1-/- cells and expression of a constitutively active Sos restored ERK activation in these cells, indicating that Gab1 functions upstream of Ras
Warnecke et al., EMBO Rep 2012 : We found that T-cell antigen receptor ( TCR ) -mediated Erk activation requires RasGRP1, but not Grb2/Sos