Peterkofsky et al., J Supramol Struct 1978
:
Evidence in support of the proposed model involves the observation that Enzyme I mutants have low cAMP levels and that PEP increases cellular cAMP levels and, under certain conditions, activates adenylate cyclase , Kinetic studies indicate that various ligands have opposing effects on adenylate cyclase
Gonzalez et al., J Supramol Struct 1977
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Previous studies have indicated that the Escherichia coli adenylate cyclase ( AC ) activity is controlled by an interaction with the phosphoenolpyruvate (PEP) : sugar phosphotransferase system (PTS)