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KL — WNT16

Text-mined interactions from Literome

Liu et al., Science 2007 : In a cell culture model, the Wnt-klotho interaction resulted in the suppression of Wnt biological activity
Lee et al., Molecular cancer 2010 (Uterine Cervical Neoplasms) : Ectopic expression of the secreted form of KLOTHO restored anti-Wnt signaling and anti-clonogenic activity in the CaSki cell line including decreased active beta-catenin levels, suppression of T-cell factor/beta-catenin target genes, such as c-MYC and CCND1, and inhibition of colony growth
Doi et al., J Biol Chem 2011 (Fibrosis...) : In addition to TGF-ß1 signaling, secreted Klotho has been shown to inhibit Wnt and IGF-1 signaling that can promote EMT
Hiyama et al., Arthritis Res Ther 2012 (Intervertebral Disc Degeneration...) : The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells ... These results suggest that the expression of Klotho is regulated by the balance between upregulation and downregulation of Wnt signaling
Hu et al., Contrib Nephrol 2013 : Unlike membrane Klotho which functions as a coreceptor for fibroblast growth factor-23 (FGF23) to modulate FGF23 signal transduction, soluble Klotho is a multifunction protein present in the biological fluids including blood, urine and cerebrospinal fluid and plays important roles in antiaging, energy metabolism, inhibition of Wnt signaling, antioxidation, modulation of ion transport, control of parathyroid hormone and 1,25 ( OH ) 2VD3 production, and antagonism of renin-angiotensin-aldosterone system