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INS — VAMP2

Text-mined interactions from Literome

Nagamatsu et al., Diabetes 1999 (Diabetes Mellitus, Type 2) : Decreased expression of t-SNARE , syntaxin 1, and SNAP-25 in pancreatic beta-cells is involved in impaired insulin secretion from diabetic GK rat islets : restoration of decreased t-SNARE proteins improves impaired insulin secretion
Kawanishi et al., J Biol Chem 2000 : Both syntaxin4 and VAMP2 are implicated in insulin regulation of glucose transporter-4 (GLUT4) trafficking in adipocytes as target ( t ) soluble N-ethylmaleimide-sensitive factor attachment protein receptors ( SNARE ) and vesicle ( v ) -SNARE proteins, respectively, which mediate fusion of GLUT4 containing vesicles with the plasma membrane
Huang et al., Am J Physiol Cell Physiol 2001 (Insulinoma...) : Previous reports showed that cleavage of vesicle associated membrane protein-2 ( VAMP-2 ) and synaptosomal associated protein of 25 kDa ( SNAP-25 ) by clostridial neurotoxins in permeabilized insulin secreting beta-cells inhibited Ca ( 2+ ) -evoked insulin secretion
Braiman et al., Mol Cell Biol 2001 : Finally, either insulin or overexpression of PKC zeta induced serine phosphorylation of the GLUT4-compartment associated vesicle associated membrane protein 2
Liu et al., J Biol Chem 2003 : On the other hand, nocodazole partially inhibited insulin induced translocation of the insulin regulated aminopeptidase and the vesicle associated membrane protein ( VAMP)-2 without affecting GLUT1 and VAMP-3
Nevins et al., J Biol Chem 2005 : A direct interaction between Cdc42 and vesicle associated membrane protein 2 regulates SNARE dependent insulin exocytosis
Tian et al., Biochem Biophys Res Commun 2008 : Insulin induces the dissociation of the Synip and Stx4 complex, and then triggers VAMP2 to interact with Stx4 to form the SNARE complex, thus promoting the vesicle fusion
Lin et al., J Cell Physiol 2011 : The purpose of this study was to test a hypothesis that T3 promotes glucose uptake via enhancing insulin induced Akt phosphorylation and VAMP2 translocation in 3T3-L1 adipocytes ... Akt phosphorylation is necessary for the promoting effects of T3 on insulin stimulated VAMP2 translocation
Regazzi et al., EMBO J 1995 : Taken together, our results show that pancreatic beta-cells express VAMP-2 and cellubrevin and that one or both of these proteins selectively control Ca ( 2+ ) -mediated insulin secretion