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EDN2 — INS
Text-mined interactions from Literome
Gottsäter et al., Scand J Clin Lab Invest 1999
:
In this study we evaluated whether
insulin affects the monocyte derived inflammatory mediator neopterin and
endothelin- in plasma ( p ), and NO and PGI2 mediators cyclic 3'-5 ' guanosine monophosphate ( cGMP ) and cyclic 3'-5 ' adenosine monophosphate ( cAMP ) in platelets
Shih et al., J Cell Biochem 2000
:
Previously, we reported that
insulin stimulated glucose uptake (ISGU) can be
inhibited by
endothelin ( ET-1 )
Lawrence et al., Mol Cell Biol 2001
:
In this study, we used a novel inducible system to rapidly and synchronously activate expression of a dominant inhibitory form of ADP-ribosylation factor 6, ARF6 ( T27N ), in 3T3-L1 adipocytes and assessed its effects on
insulin- and
endothelin stimulated hexose uptake
Piatti et al., Circulation 2003
(Angina Pectoris...) :
After insulin bolus, during saline,
insulin induced NOx,
endothelin-1 , and forearm cGMP release was almost abolished
Rubio et al., Exp Gerontol 2006
(Hypertension...) :
Effect of age on
insulin induced
endothelin release and vasoreactivity in hypertriglyceridemic and hypertensive rats ... Increased
endothelin release
induced by
insulin remained constant in normal rats, while in HTG rats it was higher than in controls at all ages
Eringa et al., Am J Physiol Endocrinol Metab 2007
(Insulin Resistance...) :
In arteries of lean rats,
insulin increased activity of both NO and
endothelin ( ET-1 ), resulting in a neutral effect under basal conditions
Hayakawa et al., Jpn J Ophthalmol 1991
:
The stimulating
effect of
insulin on retinal capillary
endothelin was more pronounced in log-phase cells than in stationary-phase cells
Metsärinne et al., Metabolism 1994
(Hyperinsulinism) :
Insulin increases the release of
endothelin in endothelial cell cultures in vitro but not in vivo
Anfossi et al., Metabolism 1993
:
Insulin at a concentration of 320 microU/mL induced a significant increase of immunoreactive endothelin levels in medium ( from 15.2 +/- 0.8 to 20.6 +/- 0.8 pg/200 microL, P < .01 ) and
potentiated arginine vasopressin- and angiotensin II-induced immunoreactive
endothelin release ( P < .0001 and P < .04, respectively ) ...
Insulin at a concentration of 80 microU/mL did not
induce a significant increase of spontaneous immunoreactive
endothelin release, but significantly increased the effects of arginine vasopressin ( P < .05 )
Andronico et al., J Hum Hypertens 1997
(Hypertension...) :
Since
endothelin production is
stimulated in vitro by
insulin , we performed this study to evaluate in vivo the relationships between endothelin and insulin plasma levels during a glucose load
Woodcock et al., Circulation 1999
(Arrhythmias, Cardiac...) :
Reperfusion in the presence of endothelin-1 alone caused no change in Ins 1,4,5P3 ( 2762+/-240 cpm/g tissue ), but when added together with thrombin or norepinephrine,
endothelin-1 reduced the
Ins 1,4,5P3 responses to 2313+/-197 and 1764+/-168 cpm/g tissue, respectively ( n=4, P < 0.01 in both cases )