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IFNG — TBX21

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → IFN-gamma (IFNG) (transcription, activates) Walker et al., J Immunol 1999*, Szabo et al., Science 2002, Morinobu et al., Proc Natl Acad Sci U S A 2002, Kaplan et al., Nature 1996
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → IFN-gamma (IFNG) (transcription, activates) Szabo et al., Science 2002, Nakahira et al., J Immunol 2002, Barbulescu et al., J Immunol 1998*
  Evidence: mutant phenotype, assay, reporter gene, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: T-bet (TBX21) → IFN-gamma (IFNG) (transcription, activates) Campbell et al., Transplantation 1996
  Evidence: physical interaction
• NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → IFN-gamma (IFNG) (transcription, activates) Cai et al., J Immunol 2000*, Schindler et al., J Immunol 2001, Szabo et al., Science 2002, Morinobu et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., J Exp Med 1989*, Hunter et al., Eur J Immunol 1995*, Kaplan et al., Nature 1996
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database IL12 signaling mediated by STAT4: T-bet (TBX21) → IFN-gamma (IFNG) (transcription, activates) Szabo et al., Science 2002, Wittmann et al., J Leukoc Biol 2006
  Evidence: mutant phenotype, assay, other species