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CCK — PKD1

Text-mined interactions from Literome

Berna et al., Biochim Biophys Acta 2007 : CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC independent pathways ... CCK activated PKD1 and caused a time- and dose dependent increase in serine phosphorylation by activation of high- and low-affinity CCK(A) receptor states ... CCK stimulated translocation of total and phosphorylated PKD1 to the membrane
Yuan et al., Am J Physiol Gastrointest Liver Physiol 2008 (Pancreatitis) : Both CCK-8 and CCh dose dependently induced a rapid and striking activation of PKD1 in rat pancreatic acinar cells, as measured by in vitro kinase assay and by phosphorylation at PKD1 activation loop ( Ser744/748 ) or autophosphorylation site ( Ser916 ) ... Either inhibition of PKCdelta or epsilon by isoform-specific inhibitory peptides, genetic deletion of PKCdelta and epsilon in pancreatic acinar cells, or knockdown of PKD1 by using small interfering RNAs in AR42J cells resulted in a marked decrease in PKD1 and NF-kappaB activation stimulated by CCK-8 or CCh. Conversely, overexpression of PKD1 resulted in augmentation of CCK-8- and CCh stimulated NF-kappaB activation