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Text-mined interactions from Literome

Heitmeier et al., J Biol Chem 1999 : Poly IC + IFN-gamma stimulates iNOS expression and inhibits insulin secretion by primary beta-cells purified by fluorescence activated cell sorting
Heitmeier et al., J Biol Chem 2001 (Diabetes Mellitus, Type 1...) : In combination, synthetic dsRNA ( polyinosinic-polycytidylic acid, poly ( I-C ) ) and interferon (IFN)-gamma stimulate inducible nitric-oxide synthase (iNOS) expression, inhibit insulin secretion, and induce islet degeneration ... Interleukin-1 (IL-1) appears to mediate dsRNA + IFN-gamma induced islet damage in a nitric oxide dependent manner, as the interleukin-1 receptor antagonist protein prevents dsRNA + IFN-gamma induced iNOS expression, inhibition of insulin secretion, and islet degeneration
Blair et al., Diabetes 2001 : Furthermore, the genetic absence of PKR did not affect dsRNA + IFN-gamma induced iNOS expression, nitric oxide production, or the inhibitory actions of these agents on glucose stimulated insulin secretion
Cottet et al., J Biol Chem 2001 (Diabetes Mellitus, Type 1) : SOCS-1 protein prevents Janus Kinase/STAT dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma ... Here, using the highly differentiated beta Tc-Tet insulin secreting cell line, we showed that IFN-gamma dose- and time-dependently suppressed insulin synthesis and glucose stimulated secretion ... Together our data demonstrate that IFN-gamma is responsible for the cytokine induced defect in insulin gene expression and secretion and that this effect can be completely blocked by constitutive inhibition of the Janus kinase/STAT pathway
Mabley et al., Br J Pharmacol 2001 (Diabetes Mellitus, Experimental) : In vitro the cytokine combination ; interleukin-1beta, tumor necrosis factor-alpha and interferon-gamma inhibited glucose stimulated insulin secretion from isolated rat islets of Langerhans and decreased RIN-5F cell viability
Wu et al., J Surg Res 2001 : We tested the in vitro effects of interleukin (IL)-1 beta, tumor necrosis factor (TNF)alpha, and interferon (IFN)gamma on glucose stimulated insulin release in the MIN6 beta-cell line and correlated metabolic dysfunction with NO production and rates of apoptosis
Baker et al., Surgery 2003 : Interferon (IFN)-gamma acts synergistically with interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha to activate isoform of nitric oxide synthetase ( iNOS ) gene expression, induce apoptosis, and impair glucose stimulated insulin release ( GSIR ) in pancreatic islets
Rasschaert et al., Diabetologia 2003 : PIC + IFN-gamma inhibited insulin and GLUT-2 expression without modifying pdx-1 mRNA expression
Rabinovitch et al., Diabetologia 1992 : The individual cytokines, interleukin 1 ( 1 U/ml ), tumour necrosis factor ( 10 ( 2 ) U/ml ), and interferon gamma ( 10 ( 2 ) U/ml ) inhibited insulin release but did not increase islet malondialdehyde levels
Faresjö et al., Diabetes Metab Res Rev 2006 (Diabetes Mellitus, Type 1) : Fasting C-peptide levels at diagnosis correlated with insulin induced IFN-gamma ( R = 0.52 ; p = 0.05 ) and negatively with spontaneous IL-4 secretion ( R = -0.62 ; p < 0.05 )
Durinovic-Belló et al., Proc Natl Acad Sci U S A 2006 : The human T cell clone was forkhead transcription factor 3 ( Foxp3 ) -positive, a marker for regulatory T cell lineages, and secreted predominantly IL-5, IL-10, and low levels of IFNgamma in response to P-Ins ( 73-90 )
Nilsson et al., Clin Exp Immunol 2006 (Celiac Disease...) : A low IFN-gamma response to insulin was found in type 1 diabetic children, whereas allergic children responded to insulin by increased IL-4 secretion
Kim et al., Pancreas 2007 : Quercetin, apigenin, and luteolin also prevented IL-1beta- and IFN-gamma mediated inhibition of insulin secretion
McGillicuddy et al., J Biol Chem 2009 (Insulin Resistance) : Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
Rabinovitch et al., Endocrinology 1990 (Necrosis) : Whereas indomethacin and NDGA did not prevent TNF/IFN-gamma induced inhibition of insulin release, this recovered after cytokine removal from cultures protected by the cyclo/lipoxygenase inhibitors
Rabinovitch et al., J Clin Endocrinol Metab 1990 : Interleukin-1 (IL-1), tumor necrosis factor (TNF), and interferon-gamma (IFN gamma) inhibit insulin release and may be cytotoxic to isolated rodent pancreatic islets
Rabinovitch et al., Reg Immunol 1989 (Diabetes Mellitus, Type 1) : When tested as single agents or added together at very low concentrations, interleukin 1 (IL-1), tumor necrosis factor (TNF), and interferon gamma (IFN-gamma) inhibited insulin release from rat islet cell monolayer cultures during 4 day incubations ; however, this secretory function improved after the cytokines were removed
Campbell et al., J Immunol 1988 : In combination, IFN-gamma and TNF-alpha each at 200 U/ml caused significant inhibition of glucose stimulated insulin release ; at 2000 U/ml glucose stimulated insulin release was abolished
Sternesjö et al., Autoimmunity 1995 : It was found that IFN-gamma reduced medium insulin accumulation and basal insulin secretion at 1.7 mM glucose, without affecting the medium nitrite level
Hansen et al., Br J Cancer 1994 (Carcinoma, Renal Cell...) : IFN-gamma caused a fourfold increase in Ins 1,4,5-P3 formation
Hansen et al., Virchows Arch B Cell Pathol 1993 (Carcinoma, Renal Cell...) : Preincubation with PT or CT for 24 h also inhibited IFN-gamma induced inositol 1-monophosphate (Ins 1-P) , inositol 1,4 bisphosphate ( Ins 1,4-P2 ) and inositol 1,4,5 trisphosphate ( Ins 1,4,5-P3 ) formation
Rabinovitch et al., Diabetologia 1994 : The individual cytokines, interleukin 1 ( 10 U/ml ), tumour recrosis factor ( 10 ( 3 ) U/ml ) and interferon gamma ( 10 ( 3 ) U/ml ) inhibited insulin release from rat islets, but did not cause DNA fragmentation or destroy islet cells ; by contrast, combination of the three cytokines induced DNA fragmentation and islet-cell death
McRoberts et al., Am J Physiol 1994 : Together, these results strongly suggest that insulin , insulin-like growth factors, and interferon-gamma increase the permeability across T84 cell monolayers through a common mechanism that is modulated by glucose derived metabolites and oxidative metabolism
Dunger et al., Diabetes 1996 : Tumor necrosis factor-alpha and interferon-gamma inhibit insulin secretion and cause DNA damage in unweaned-rat islets ... The aim of this study was to define the effects of tumor necrosis factor-alpha (TNF) and interferon-gamma (IFN) on nitric oxide production, insulin secretion, and DNA damage in islets from unweaned rats
Galdiero et al., Eur Cytokine Netw 1995 : Effect of growth hormone, prolactin and insulin on the release of IL-1 alpha, IFN-gamma and IL-4 by staphylococcal enterotoxin A-stimulated splenocytes
Vitiello et al., Immunol Cell Biol 1995 : Prolactin and insulin regulate the release of IL-1-alpha and IFN-gamma from murine splenocytes activated with porins or LPS of Salmonella typhimurium
Hao et al., Autoimmunity 1995 : 3 ) IFN gamma at doses of 10, 100, 1000 U/ml had no effect on insulin secretion or on GAD-65 expression
Huppertz et al., Diabetologia 1996 : The effects of insulin, insulin-like growth factor (IGF)-I, platelet derived growth factor ( PDGF ), interleukin (IL)-6 and interferon-gamma on 2-deoxyglucose uptake and insulin receptor substrate (IRS)-1 phosphorylation were compared in 3T3-L1 cells at confluence and after differentiation to the adipocyte-like phenotype
de-Mello et al., Biochem Pharmacol 1996 (Insulinoma...) : However, ebselen failed to prevent the increase in nitrite production and the decrease in glucose oxidation and insulin release by rat islets exposed to IL-1 beta for 24 hr. Ebselen prevented the increase in nitrite production by human islets exposed for 14 hr to a combination of cytokines ( IL-1 beta, tumor necrosis factor-alpha and interferon-gamma )
Baldeón et al., Diabetes 1997 : Time-course analysis of IFN-gamma regulated mRNA expression of the two intra-MHC encoded subunits of the proteasome ( low-molecular-mass polypeptide [ Lmp]-2 and Lmp-7 ) revealed a correlation between their induction and the inhibitory effects of IFN-gamma on glucose stimulated insulin production
Heitmeier et al., J Biol Chem 1997 : The purpose of this study was to evaluate the effects of interferon-gamma (IFN-gamma) alone and in combination with interleukin 1beta (IL-1beta) on inducible nitric-oxide synthase (iNOS) mRNA and protein expression, nitrite production, and insulin secretion by islets of Langerhans
Laffranchi et al., Exp Cell Res 1997 : Interferon-gamma inhibits insulin release and induces cell death in the pancreatic beta-cell line INS-1 independently of nitric oxide production
Arnush et al., J Clin Invest 1998 : Inhibition of iNOS activity by aminoguanidine also attenuates TNF + LPS + IFN-gamma induced inhibition of insulin secretion by human islets