Park et al., J Biol Chem 2004
(Fibrosarcoma) :
The interferon-gamma induced inhibition of ASK1 activity was blocked by N ( G ) -nitro-l-arginine, an inhibitor of NO synthase ... Together, these results suggest that NO mediates the interferon-gamma induced inhibition of ASK1 in L929 cells through a thiolredox mechanism
Yu et al., J Biol Chem 2009
:
Interferon-gamma (IFN-gamma) induced degradation of ASK1 in normal but not in SOCS1-KO endothelial cells ( EC ) ... IFN-gamma induced tyrosine phosphorylation of ASK1 at Tyr-718 was blocked by a JAK2-specific inhibitor ... IFN-gamma enhanced the association between JAK2 and ASK1 , and the ASK1-JAK2 complex was labile and was stabilized by the proteasomal inhibitor MG132