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ATP7A — IL6
Text-mined interactions from Literome
Rowlett et al., Am J Physiol Gastrointest Liver Physiol 2008
(Crohn Disease...) :
MNK inhibition also
blocked IL-6 but permitted IL-10 production in response to LPS
Patel et al., Biometals 2013
:
Neocuproine, but not
ATP7A deficiency,
reduced the production of FGF-9, IL-1a, IL-12p70, IL-2, IL-3, IL-4,
IL-6 , MIP-1ß, MIP-2, RANTES, and TNFa
Fukunaga et al., EMBO J 1997
:
Further,
MNK1 was activated upon
stimulation of HeLa cells with 12-O-tetradecanoylphorbol-13-acetate, fetal calf serum, anisomycin, UV irradiation, tumor necrosis factor-alpha,
interleukin-1beta , or osmotic shock, and the activation by these stimuli was differentially inhibited by the MEK inhibitor PD098059 or the p38 MAP kinase inhibitor SB202190