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CSN3 — EGF
Text-mined interactions from Literome
Benton et al., Endocrinology 1999
:
Culture of primary rat mammary epithelial cells ( RMEC ) under lactogenic conditions revealed that expression of
beta-casein was
independent of
epidermal growth factor (EGF) in RMEC from virgin WKYv, but was dependent in WFv, RMEC
Galbaugh et al., BMC cell biology 2006
:
The expression of CA-Akt inhibited lactogenic differentiation of HC11 cells, and the infection with DN-Akt adenovirus enhanced
beta-casein transcription and rescued beta-casein promotor regulated luciferase activity in the
presence of
EGF
Ackerman et al., J Biol Chem 1989
:
Regulation of
casein kinase II activity by
epidermal growth factor in human A-431 carcinoma cells
Arakawa et al., Exp Cell Res 1985
:
Epidermal growth factor (EGF) inhibited
casein production and the accumulation of casein mRNA activity induced by insulin (I), cortisol ( F ) and prolactin (P) in a primary culture of mammary epithelial cells from pregnant mice ... Dibutyryl cyclic AMP ( db-cAMP ), cAMP, and 3-isobutylmethylxanthine ( IBMX ), an inhibitor of phosphodiesterase, also antagonized the inhibitory
effect of
EGF on
casein production ... These results suggest a possible modulatory role of cAMP in
EGF induced inhibition of
casein production in cultured mammary epithelial cells
Sankaran et al., Biochem Biophys Res Commun 1987
:
It has been observed that
EGF inhibits the induction of
casein synthesis by mouse mammary tissue in vitro in addition to acting as a promoter of mammary epithelial proliferation ... The current studies demonstrate, in fact, that
EGF inhibits the induction of
casein synthesis in vitro only when insulin is present in the culture medium at unphysiologically high concentrations
Komura et al., Endocrinology 1986
:
EGF inhibited the synthesis of
casein and decreased alpha-lactalbumin activity of mammary explants in culture in the presence of insulin, cortisol, and PRL ... Concomitant addition of retinoic acid with EGF had no significant effect on
EGF induced inhibition of
casein synthesis, but enhanced EGF induced inhibition of alpha-lactalbumin activity dose dependently
Taketani et al., Endocrinology 1983
:
In contrast,
EGF inhibited hormonal induction of the synthesis of
casein and alpha-lactalbumin in those cells by about 45 % and 55 %, respectively, without inhibiting total protein synthesis
Darcy et al., J Cell Physiol 1995
:
Prolactin ( 0.01-10 micrograms/ml ) and
EGF ( 1-100 ng/ml ) were each
required for induction of cell growth, extensive alveolar, as well as multilobular branching morphogenesis, and
casein accumulation
Nishikawa et al., Am J Physiol 1994
:
Progesterone and
EGF inhibit mouse mammary gland prolactin receptor and
beta-casein gene expression